@inbook{d890701fbc404249b95f7c8a52b542c8,
title = "Adult Stem Cell Niches. Cellular and Molecular Components.",
abstract = "As stem cells (SCs) in adult organs continue to be identified and characterized, it becomes clear that their survival, quiescence, and activation depend on specific signals in their microenvironment, or niche. Although adult SCs of diverse tissues differ by their developmental origin, cycling activity, and regenerative capacity, there appear to be conserved similarities regarding the cellular and molecular components of the SC niche. Interestingly, many organs house both slow-cycling and fast-cycling SC populations, which rely on the coexistence of quiescent and inductive niches for proper regulation. In this review we present a general definition of adult SC niches in the most studied mammalian systems. We further focus on dissecting their cellular organization and on highlighting recently identified key molecular regulators. Finally, we detail the potential involvement of the SC niche in tissue degeneration, with a particular emphasis on aging and cancer.",
keywords = "Activation, Adult stem cells, Quiescence, Self-renewal, Signaling, Stem cell niche",
author = "Am{\'e}lie Rezza and Rachel Sennett and Michael Rendl",
note = "Funding Information: We apologize to all colleagues whose relevant work we could not discuss due to space limitations. R. S. was supported by training grant T32GM008553 from NIH/NIGMS. M. R. was supported by a Dermatology Foundation Research Career Development Award, by NYSTEM contracts C026410 and C026411, and by grants from the NIH/NIAMS (R01AR059143; R01AR063151).",
year = "2014",
doi = "10.1016/B978-0-12-416022-4.00012-3",
language = "English",
series = "Current Topics in Developmental Biology",
publisher = "Academic Press Inc.",
pages = "333--372",
booktitle = "Current Topics in Developmental Biology",
address = "United States",
}