TY - JOUR
T1 - Adult Outcome of ADHD
T2 - An Overview of Results From the MGH Longitudinal Family Studies of Pediatrically and Psychiatrically Referred Youth With and Without ADHD of Both Sexes
AU - Uchida, Mai
AU - Spencer, Thomas J.
AU - Faraone, Stephen V.
AU - Biederman, Joseph
N1 - Publisher Copyright:
© 2015, © The Author(s) 2015.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Objective: We aimed to provide an overview of the Massachusetts General Hospital (MGH) Longitudinal Studies of ADHD. Methods: We evaluated and followed samples of boys and girls with and without ADHD ascertained from psychiatric and pediatric sources and their families. Results: These studies documented that ADHD in both sexes is associated with high levels of persistence into adulthood, high levels of familiality with ADHD and other psychiatric disorders, a wide range of comorbid psychiatric and cognitive disorders including mood, anxiety, and substance use disorders, learning disabilities, executive function deficits, emotional dysregulation, and autistic traits as well as functional impairments. The MGH studies suggested that stimulant treatment decreased risks of developing comorbid psychiatric disorders, substance use disorders, and functional outcomes. The MGH studies documented the neural basis of persistence of ADHD using neuroimaging. Conclusion: The MGH studies provided various insights on symptoms, course, functions, comorbidities, and neuroscience of ADHD.
AB - Objective: We aimed to provide an overview of the Massachusetts General Hospital (MGH) Longitudinal Studies of ADHD. Methods: We evaluated and followed samples of boys and girls with and without ADHD ascertained from psychiatric and pediatric sources and their families. Results: These studies documented that ADHD in both sexes is associated with high levels of persistence into adulthood, high levels of familiality with ADHD and other psychiatric disorders, a wide range of comorbid psychiatric and cognitive disorders including mood, anxiety, and substance use disorders, learning disabilities, executive function deficits, emotional dysregulation, and autistic traits as well as functional impairments. The MGH studies suggested that stimulant treatment decreased risks of developing comorbid psychiatric disorders, substance use disorders, and functional outcomes. The MGH studies documented the neural basis of persistence of ADHD using neuroimaging. Conclusion: The MGH studies provided various insights on symptoms, course, functions, comorbidities, and neuroscience of ADHD.
KW - ADHD
KW - adult
KW - longitudinal study
KW - outcomes
UR - http://www.scopus.com/inward/record.url?scp=85044108266&partnerID=8YFLogxK
U2 - 10.1177/1087054715604360
DO - 10.1177/1087054715604360
M3 - Article
C2 - 26396145
AN - SCOPUS:85044108266
SN - 1087-0547
VL - 22
SP - 523
EP - 534
JO - Journal of Attention Disorders
JF - Journal of Attention Disorders
IS - 6
ER -