Adult-onset hemiplegic migraine with cortical enhancement and oedema

Y. H. Cha; D. Millett; M. Kane; J. Jen; R. Baloh

doi:10.1111/j.1468-2982.2007.01369.x

Adult-onset hemiplegic migraine with cortical enhancement and oedema

Y. H. Cha, D. Millett, M. Kane, J. Jen, R. Baloh

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

We present genetically identical twin patients who experienced late-onset migraine with visual and somatosensory auras and later developed hemiplegic migraines associated with severe cortical oedema and enhancement. Both positron emission tomography and electroencephalography showed an increase in activity contralateral to the hemiplegic side. Brain biopsy during the attack showed reactive astrogliosis and microgliosis. Mutations in CACNA1A, ATP1A2, SLC1A3 and NOTCH3 were ruled out by sequencing. This report shows the clinical and genetic evaluation of a severe form of familial hemiplegic migraine as well as the evolution of the imaging changes.

Original language	English
Pages (from-to)	1166-1170
Number of pages	5
Journal	Cephalalgia
Volume	27
Issue number	10
DOIs	https://doi.org/10.1111/j.1468-2982.2007.01369.x
State	Published - Oct 2007
Externally published	Yes

Keywords

Cortical oedema
Hemiplegic migraine
Migraine with aura

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10.1111/j.1468-2982.2007.01369.x

Cite this

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title = "Adult-onset hemiplegic migraine with cortical enhancement and oedema",

abstract = "We present genetically identical twin patients who experienced late-onset migraine with visual and somatosensory auras and later developed hemiplegic migraines associated with severe cortical oedema and enhancement. Both positron emission tomography and electroencephalography showed an increase in activity contralateral to the hemiplegic side. Brain biopsy during the attack showed reactive astrogliosis and microgliosis. Mutations in CACNA1A, ATP1A2, SLC1A3 and NOTCH3 were ruled out by sequencing. This report shows the clinical and genetic evaluation of a severe form of familial hemiplegic migraine as well as the evolution of the imaging changes.",

keywords = "Cortical oedema, Hemiplegic migraine, Migraine with aura",

author = "Cha, {Y. H.} and D. Millett and M. Kane and J. Jen and R. Baloh",

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AU - Cha, Y. H.

AU - Millett, D.

AU - Kane, M.

AU - Jen, J.

AU - Baloh, R.

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N2 - We present genetically identical twin patients who experienced late-onset migraine with visual and somatosensory auras and later developed hemiplegic migraines associated with severe cortical oedema and enhancement. Both positron emission tomography and electroencephalography showed an increase in activity contralateral to the hemiplegic side. Brain biopsy during the attack showed reactive astrogliosis and microgliosis. Mutations in CACNA1A, ATP1A2, SLC1A3 and NOTCH3 were ruled out by sequencing. This report shows the clinical and genetic evaluation of a severe form of familial hemiplegic migraine as well as the evolution of the imaging changes.

AB - We present genetically identical twin patients who experienced late-onset migraine with visual and somatosensory auras and later developed hemiplegic migraines associated with severe cortical oedema and enhancement. Both positron emission tomography and electroencephalography showed an increase in activity contralateral to the hemiplegic side. Brain biopsy during the attack showed reactive astrogliosis and microgliosis. Mutations in CACNA1A, ATP1A2, SLC1A3 and NOTCH3 were ruled out by sequencing. This report shows the clinical and genetic evaluation of a severe form of familial hemiplegic migraine as well as the evolution of the imaging changes.

KW - Cortical oedema

KW - Hemiplegic migraine

KW - Migraine with aura

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Adult-onset hemiplegic migraine with cortical enhancement and oedema

Abstract

Keywords

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