Adult Human Glioblastomas Harbor Radial Glia-like Cells

Rong Wang, Roshan Sharma, Xiaojuan Shen, Ashley M. Laughney, Kosuke Funato, Philip J. Clark, Monika Shpokayte, Peter Morgenstern, Monalisa Navare, Yichi Xu, Shaghayegh Harbi, Ignas Masilionis, Gouri Nanjangud, Yanhong Yang, Gabriel Duran-Rehbein, Martin Hemberg, Dana Pe'er, Viviane Tabar

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Tabar and colleagues report that adult brain tumors comprise neoplastic radial glia-like cells reminiscent of normal radial glia of early development. They are responsive to inflammation signals and may represent putative stem cells of origin of this lethal tumor.

Original languageEnglish
Pages (from-to)338-350
Number of pages13
JournalStem Cell Reports
Volume14
Issue number2
DOIs
StatePublished - 11 Feb 2020
Externally publishedYes

Keywords

  • brain tumor
  • cancer stem cells
  • glioblastoma
  • inflammation
  • radial glia
  • scRNASeq
  • tumor mitosis

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