Adult Human Glioblastomas Harbor Radial Glia-like Cells

Rong Wang; Roshan Sharma; Xiaojuan Shen; Ashley M. Laughney; Kosuke Funato; Philip J. Clark; Monika Shpokayte; Peter Morgenstern; Monalisa Navare; Yichi Xu; Shaghayegh Harbi; Ignas Masilionis; Gouri Nanjangud; Yanhong Yang; Gabriel Duran-Rehbein; Martin Hemberg; Dana Pe'er; Viviane Tabar

doi:10.1016/j.stemcr.2020.01.007

Adult Human Glioblastomas Harbor Radial Glia-like Cells

Rong Wang, Roshan Sharma, Xiaojuan Shen, Ashley M. Laughney, Kosuke Funato, Philip J. Clark, Monika Shpokayte, Peter Morgenstern, Monalisa Navare, Yichi Xu, Shaghayegh Harbi, Ignas Masilionis, Gouri Nanjangud, Yanhong Yang, Gabriel Duran-Rehbein, Martin Hemberg, Dana Pe'er, Viviane Tabar

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Tabar and colleagues report that adult brain tumors comprise neoplastic radial glia-like cells reminiscent of normal radial glia of early development. They are responsive to inflammation signals and may represent putative stem cells of origin of this lethal tumor.

Original language	English
Pages (from-to)	338-350
Number of pages	13
Journal	Stem Cell Reports
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/j.stemcr.2020.01.007
State	Published - 11 Feb 2020
Externally published	Yes

Keywords

brain tumor
cancer stem cells
glioblastoma
inflammation
radial glia
scRNASeq
tumor mitosis

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10.1016/j.stemcr.2020.01.007

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Wang, R., Sharma, R., Shen, X., Laughney, A. M., Funato, K., Clark, P. J., Shpokayte, M., Morgenstern, P., Navare, M., Xu, Y., Harbi, S., Masilionis, I., Nanjangud, G., Yang, Y., Duran-Rehbein, G., Hemberg, M., Pe'er, D., & Tabar, V. (2020). Adult Human Glioblastomas Harbor Radial Glia-like Cells. Stem Cell Reports, 14(2), 338-350. https://doi.org/10.1016/j.stemcr.2020.01.007

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title = "Adult Human Glioblastomas Harbor Radial Glia-like Cells",

abstract = "Tabar and colleagues report that adult brain tumors comprise neoplastic radial glia-like cells reminiscent of normal radial glia of early development. They are responsive to inflammation signals and may represent putative stem cells of origin of this lethal tumor.",

keywords = "brain tumor, cancer stem cells, glioblastoma, inflammation, radial glia, scRNASeq, tumor mitosis",

author = "Rong Wang and Roshan Sharma and Xiaojuan Shen and Laughney, {Ashley M.} and Kosuke Funato and Clark, {Philip J.} and Monika Shpokayte and Peter Morgenstern and Monalisa Navare and Yichi Xu and Shaghayegh Harbi and Ignas Masilionis and Gouri Nanjangud and Yanhong Yang and Gabriel Duran-Rehbein and Martin Hemberg and Dana Pe'er and Viviane Tabar",

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doi = "10.1016/j.stemcr.2020.01.007",

language = "English",

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AU - Wang, Rong

AU - Sharma, Roshan

AU - Shen, Xiaojuan

AU - Laughney, Ashley M.

AU - Funato, Kosuke

AU - Clark, Philip J.

AU - Shpokayte, Monika

AU - Morgenstern, Peter

AU - Navare, Monalisa

AU - Xu, Yichi

AU - Harbi, Shaghayegh

AU - Masilionis, Ignas

AU - Nanjangud, Gouri

AU - Yang, Yanhong

AU - Duran-Rehbein, Gabriel

AU - Hemberg, Martin

AU - Pe'er, Dana

AU - Tabar, Viviane

PY - 2020/2/11

Y1 - 2020/2/11

N2 - Tabar and colleagues report that adult brain tumors comprise neoplastic radial glia-like cells reminiscent of normal radial glia of early development. They are responsive to inflammation signals and may represent putative stem cells of origin of this lethal tumor.

AB - Tabar and colleagues report that adult brain tumors comprise neoplastic radial glia-like cells reminiscent of normal radial glia of early development. They are responsive to inflammation signals and may represent putative stem cells of origin of this lethal tumor.

KW - brain tumor

KW - cancer stem cells

KW - glioblastoma

KW - inflammation

KW - radial glia

KW - scRNASeq

KW - tumor mitosis

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SP - 338

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JO - Stem Cell Reports

JF - Stem Cell Reports

IS - 2

ER -

Adult Human Glioblastomas Harbor Radial Glia-like Cells

Abstract

Keywords

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