Adult, adolescent, and caregiver preferences for attributes of topical treatments for mild-to-moderate atopic dermatitis: a discrete-choice experiment

Steven R. Feldman, Jacob P. Thyssen, Marco Boeri, Robert Gerber, Maureen P. Neary, Amy Cha, Brett Hauber, Joseph C. Cappelleri, Jason Xenakis, Colton Leach, Joshua Zeichner

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Topical treatments for mild-to-moderate (MM) atopic dermatitis (AD) include emollients, corticosteroids, calcineurin inhibitors, a Janus kinase inhibitor, and a phosphodiesterase 4 inhibitor, which differ in multiple ways. This study aimed to quantify the conditional relative importance (CRI) of attributes of topical treatments for MM AD among adult and adolescent patients and caregivers of children with MM AD. Materials and methods: A discrete-choice experiment (DCE) survey was administered to US adults and adolescents with MM AD and caregivers of children with MM AD. Each choice task comprised 2 hypothetical topical treatments characterized by efficacy, adverse events, vehicle, and application frequency. Data were analyzed using a random-parameters logit model to calculate the CRI of each attribute. Results and conclusions: 300 adults, 331 adolescents, and 330 caregivers completed the DCE. Avoiding changes in skin color (CRI 29.0) and time until itch improves (26.6) were most important to adults, followed by time until clear/almost clear skin (17.8). Application frequency (3.0) did not have a statistically significant impact on adults’ choices. Adolescents were less concerned about changes in skin color than adults or caregivers; caregivers were less concerned about time until clear/almost clear skin than patients. Physicians should consider age-relevant aspects of preferences in treatment discussions with patients and caregivers.

Original languageEnglish
Article number2304020
JournalJournal of Dermatological Treatment
Volume35
Issue number1
DOIs
StatePublished - 2024

Keywords

  • Atopic dermatitis
  • caregiver
  • discrete-choice experiment
  • patient
  • preferences

Fingerprint

Dive into the research topics of 'Adult, adolescent, and caregiver preferences for attributes of topical treatments for mild-to-moderate atopic dermatitis: a discrete-choice experiment'. Together they form a unique fingerprint.

Cite this