Adrenocorticotropic hormone testing in idiopathic hirsutism and polycystic ovarian disease: A test of limited usefulness

R. H. Cobin, W. Futterweit, R. P. Fiedler, J. C. Thornton

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

The plasma 17α-hydroxyprogesterone (17-OHP) concentration was determined in the basal state and 60 minutes after cosyntropin, 0.25 mg, in 139 patients with idiopathic hirsutism (IH) and polycystic ovarian disease (PCOD). Although there was an increased response of 17-OHP in subjects with PCOD when compared with IH subjects, in no instance was stimulated 17-OHP abnormal in the presence of normal basal 17-OHP. Two subjects with 21-hydroxylase (21-OH) deficiency were discovered; both demonstrated elevated basal levels of 17-OHP. We therefore conclude that routine adrenocorticotropic hormone testing is not a useful tool in detecting 21-OH deficiency in hyperandrogenic women.

Original languageEnglish
Pages (from-to)224-226
Number of pages3
JournalFertility and Sterility
Volume44
Issue number2
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Dive into the research topics of 'Adrenocorticotropic hormone testing in idiopathic hirsutism and polycystic ovarian disease: A test of limited usefulness'. Together they form a unique fingerprint.

Cite this