Adrenocorticosteroid Therapy and Peptic-Ulcer Disease

Harold O. Conn, Thierry Poynard, Julio Messer, Dinah Reitman, Henry S. Sacks, Harry Smith, Thomas C. Chalmers

Research output: Contribution to journalLetterpeer-review

7 Scopus citations


To the Editor: In 1976 one of us (H.O.C.) and Blitzer reported that the frequency of peptic ulcer in steroid-treated and control patients in randomized clinical trials was similar.1 Recently Messer et al., using a similar design, reported that peptic ulcers occurred more frequently in steroid-treated patients (P<0.001).2 The reasons for this different conclusion, based on more studies (71 vs. 50) but fewer patients (5961 vs. 6102), lie in the selection of studies and in different assumptions and interpretations, Our analysis of Messer's 71 studies reveals that 32 did not satisfy their own criteria: in some, side effects of steroids.

Original languageEnglish
Pages (from-to)201-202
Number of pages2
JournalNew England Journal of Medicine
Issue number3
StatePublished - 19 Jan 1984


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