TY - JOUR
T1 - Adrenergic stimulation decreases osteoblast oxytocin synthesis
AU - Cuscito, Concetta
AU - Colaianni, Graziana
AU - Tamma, Roberto
AU - Greco, Giovanni
AU - Dell'Endice, Stefania
AU - Yuen, Tony
AU - Sun, Li
AU - Zaidi, Mone
AU - Di Benedetto, Adriana
AU - Zallone, Alberta
PY - 2011/11
Y1 - 2011/11
N2 - Oxytocin (OT) regulates bone mass by inducing the differentiation of osteoblasts to a mature, mineralizing phenotype. We have shown recently that osteoblasts can synthesize OT. In view of known interactions between OT-ergic and adrenergic neurons in the central nervous system, we questioned whether the negative regulation of osteoblast differentiation by adrenergic nerves was mediated through its suppression of OT synthesis. We first confirmed that α1b and β2 adrenergic receptors were expressed on both primary murine osteoblasts and MC3T3-E1 cells. We then showed that α1 and β2 adrenergic agonists downregulated OT synthesis, and that the effect of each agonist was reversed by its respective antagonist. The data suggest that the negative effects of adrenergic stimulation on bone mass could, in part, arise from decreased OT synthesis.
AB - Oxytocin (OT) regulates bone mass by inducing the differentiation of osteoblasts to a mature, mineralizing phenotype. We have shown recently that osteoblasts can synthesize OT. In view of known interactions between OT-ergic and adrenergic neurons in the central nervous system, we questioned whether the negative regulation of osteoblast differentiation by adrenergic nerves was mediated through its suppression of OT synthesis. We first confirmed that α1b and β2 adrenergic receptors were expressed on both primary murine osteoblasts and MC3T3-E1 cells. We then showed that α1 and β2 adrenergic agonists downregulated OT synthesis, and that the effect of each agonist was reversed by its respective antagonist. The data suggest that the negative effects of adrenergic stimulation on bone mass could, in part, arise from decreased OT synthesis.
KW - Adrenergic receptors
KW - Bone remodeling
KW - Osteoblast
KW - Oxytocin
UR - http://www.scopus.com/inward/record.url?scp=81255210504&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2011.06235.x
DO - 10.1111/j.1749-6632.2011.06235.x
M3 - Article
AN - SCOPUS:81255210504
SN - 0077-8923
VL - 1237
SP - 53
EP - 57
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
IS - 1
ER -