Adrenergic stimulation decreases osteoblast oxytocin synthesis

Concetta Cuscito, Graziana Colaianni, Roberto Tamma, Giovanni Greco, Stefania Dell'Endice, Tony Yuen, Li Sun, Mone Zaidi, Adriana Di Benedetto, Alberta Zallone

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Oxytocin (OT) regulates bone mass by inducing the differentiation of osteoblasts to a mature, mineralizing phenotype. We have shown recently that osteoblasts can synthesize OT. In view of known interactions between OT-ergic and adrenergic neurons in the central nervous system, we questioned whether the negative regulation of osteoblast differentiation by adrenergic nerves was mediated through its suppression of OT synthesis. We first confirmed that α1b and β2 adrenergic receptors were expressed on both primary murine osteoblasts and MC3T3-E1 cells. We then showed that α1 and β2 adrenergic agonists downregulated OT synthesis, and that the effect of each agonist was reversed by its respective antagonist. The data suggest that the negative effects of adrenergic stimulation on bone mass could, in part, arise from decreased OT synthesis.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalAnnals of the New York Academy of Sciences
Volume1237
Issue number1
DOIs
StatePublished - Nov 2011

Keywords

  • Adrenergic receptors
  • Bone remodeling
  • Osteoblast
  • Oxytocin

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