Adrenal neuropeptide Y mRNA but not preproenkephalin mRNA induction by stress is impaired by aging in Fischer 344 rats

Jeffrey H. Silverstein, Joseph Beasley, Tooru M. Mizuno, Evan London, Charles V. Mobbs

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Relatively few molecular markers of stress have been studied in aged individuals. Interactions of age and stress on adrenal neuropeptide Y (NPY) and preproenkephalin (ppENK) expression have not been reported. The purpose of these studies was to characterize the adrenal NPY and ppENK responses to stress using a common stressor, physical restraint for 2 h, in Fischer 344 rats at 7, 16 and 23 months of age. Northern blot techniques were used to evaluate induction by stress of adrenal NPY mRNA and adrenal ppENK mRNA. Two humoral responses to stress, serum glucose and corticosterone, were measured to corroborate that a stress response occurred. We observed that the induction by stress of adrenal NPY mRNA is impaired with age but the stress-induced elevation of adrenal ppENK mRNA, blood glucose, and corticosterone show no evidence of age-related impairments.

Original languageEnglish
Pages (from-to)233-243
Number of pages11
JournalMechanisms of Ageing and Development
Volume101
Issue number3
DOIs
StatePublished - 1 Apr 1998

Keywords

  • Adrenal
  • Aging
  • Enkephalins
  • Glucose
  • Mechanical
  • Neuropeptide Y
  • Stress

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