Adjuvant external beam radiotherapy for locally invasive papillary thyroid cancer

Uchechukwu C. Megwalu, Lisa A. Orloff, Yifei Ma

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Background: The goal of this study was to assess the impact of adjuvant external beam radiotherapy (EBRT) on survival in patients with locally invasive papillary thyroid carcinoma. Methods: Propensity score analysis was performed on 870 patients with surgically resected T4 papillary thyroid carcinoma, identified in the Surveillance, Epidemiology, and End Results Database between 1988 and 2013. Results: EBRT was associated with worse overall survival (OS) (HR 1.60, 95% CI 1.18-2.16) and disease-specific survival (DSS) (HR 1.58, 1.09-2.30). Subset analysis of patients with major extrathyroidal invasion showed that EBRT was associated with worse OS (HR 1.53, 95% CI 1.04-2.25), but not with DSS (HR 1.57, 95% CI 0.99-2.50). Conclusion: Adjuvant EBRT, in the initial management of locally invasive papillary thyroid cancer, was not associated with a survival benefit. Future studies are needed to determine which subset of patients may benefit from adjuvant EBRT.

Original languageEnglish
Pages (from-to)1719-1724
Number of pages6
JournalHead and Neck
Issue number6
StatePublished - Jun 2019
Externally publishedYes


  • SEER program
  • propensity score
  • radiotherapy
  • survival
  • thyroid cancer


Dive into the research topics of 'Adjuvant external beam radiotherapy for locally invasive papillary thyroid cancer'. Together they form a unique fingerprint.

Cite this