Abstract
One hundred women with primary breast cancer with 4 or more metastatic axillary nodes were treated for 9 months postoperatively with vincristine, prednisone, cyclophosphamide, methotrexate, and fluorouracil (VPCMF). Sixty‐five women have been observed for a minimum of 5 years or until failure and the rest for 3 years or more. For 73 women who received adjuvant chemotherapy only, observed for 5 1/2 years median, disease‐free status by life table analysis is 68% at 8 years. No significant difference was found between response of pre‐ and postmenopausal women in disease‐free interval or survival. Mortality compared to expectation was sharply reduced; only 9 of 73 have died. These findings demonstrate the long term effectiveness of relatively short‐term surgical adjuvant combination chemotherapy in pre‐ and postmenopausal patients with breast cancer at righ risk.
| Original language | English |
|---|---|
| Pages (from-to) | 793-798 |
| Number of pages | 6 |
| Journal | Cancer |
| Volume | 44 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1979 |
| Externally published | Yes |