Purpose of Review: To highlight emerging adjunctive neuroprotective agents for treatment of hypoxic ischemic encephalopathy (HIE). Summary: HIE is a common cause of neonatal neurologic morbidity and mortality. Therapeutic hypothermia is a standard therapy, but neuroprotection is incomplete. There are several potential adjunctive agents that can be used to augment neuroprotection when combined with hypothermia. Recent Findings: Several recent studies have evaluated the use of adjunctive therapies that, when used in combination with therapeutic hypothermia, may improve short- and long-term outcomes.