Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications

Mi Jeong Lee; Yuanyuan Wu; Susan K. Fried

doi:10.1016/j.mam.2012.10.001

Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications

Mi Jeong Lee, Yuanyuan Wu, Susan K. Fried

Research output: Contribution to journal › Review article › peer-review

616 Scopus citations

Abstract

Obesity, defined as excess fat mass, increases risks for multiple metabolic diseases, such as type 2 diabetes, cardiovascular disease and several types of cancer. Over and above fat mass per se, the pattern of fat distribution, android or truncal as compared to gynoid or peripheral, has a profound influence on systemic metabolism and hence risk for metabolic diseases. Increases in upper body adipose tissue (visceral and abdominal subcutaneous) confer an independent risk, while the quantity of gluteofemoral adipose tissue is protective. Variations in the capacity of different depots to store and release fatty acids and to produce adipokines are important determinants of fat distribution and its metabolic consequences. Depot differences in cellular composition and physiology, including innervation and blood flow, likely influence their phenotypic properties. A number of lines of evidence also support the idea that adipocytes from different anatomical depots are intrinsically different as a result of genetic or developmental events. In this chapter, we will review the phenotypic characteristics of different adipose depots and mechanisms that link their depot-specific biology to metabolic complications in men and women.

Original language	English
Pages (from-to)	1-11
Number of pages	11
Journal	Molecular Aspects of Medicine
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.mam.2012.10.001
State	Published - Feb 2013
Externally published	Yes

Keywords

C-reactive protein
CLS
CRP
FFA
GLUT4
GM-CSF
IL-6
LPL
MCP-1
RBP4
SAA
SAT
SVC
TG
TNF-α
TSP-1
VAT
VLDL
crown like structures
free fatty acids
glucose transporter 4
granulocyte-macrophage colony stimulating factor
interleukin-6
lipoprotein lipase
macrophage chemoattractant protein-1
retinol binding protein 4
sc
serum amyloid A
stromal vascular cells
subcutaneous
subcutaneous adipose tissue
thrombospondin 1
triacylglyeride
tumor necrosis factor-alpha
very low density lipoprotein
visceral adipose tissue

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10.1016/j.mam.2012.10.001

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title = "Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications",

abstract = "Obesity, defined as excess fat mass, increases risks for multiple metabolic diseases, such as type 2 diabetes, cardiovascular disease and several types of cancer. Over and above fat mass per se, the pattern of fat distribution, android or truncal as compared to gynoid or peripheral, has a profound influence on systemic metabolism and hence risk for metabolic diseases. Increases in upper body adipose tissue (visceral and abdominal subcutaneous) confer an independent risk, while the quantity of gluteofemoral adipose tissue is protective. Variations in the capacity of different depots to store and release fatty acids and to produce adipokines are important determinants of fat distribution and its metabolic consequences. Depot differences in cellular composition and physiology, including innervation and blood flow, likely influence their phenotypic properties. A number of lines of evidence also support the idea that adipocytes from different anatomical depots are intrinsically different as a result of genetic or developmental events. In this chapter, we will review the phenotypic characteristics of different adipose depots and mechanisms that link their depot-specific biology to metabolic complications in men and women.",

keywords = "C-reactive protein, CLS, CRP, FFA, GLUT4, GM-CSF, IL-6, LPL, MCP-1, RBP4, SAA, SAT, SVC, TG, TNF-α, TSP-1, VAT, VLDL, crown like structures, free fatty acids, glucose transporter 4, granulocyte-macrophage colony stimulating factor, interleukin-6, lipoprotein lipase, macrophage chemoattractant protein-1, retinol binding protein 4, sc, serum amyloid A, stromal vascular cells, subcutaneous, subcutaneous adipose tissue, thrombospondin 1, triacylglyeride, tumor necrosis factor-alpha, very low density lipoprotein, visceral adipose tissue",

author = "Lee, {Mi Jeong} and Yuanyuan Wu and Fried, {Susan K.}",

note = "Funding Information: This work was supported by NIH DK52398 , DK080448 , P30 DK046200 ( BNORC ) and the Society for Women{\textquoteright}s Health Research, ISIS Foundation . We thank Dr. Karastergiou for careful reading of the manuscript.",

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doi = "10.1016/j.mam.2012.10.001",

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T2 - Implication of depot differences in adipose tissue for obesity complications

AU - Lee, Mi Jeong

AU - Wu, Yuanyuan

AU - Fried, Susan K.

N1 - Funding Information: This work was supported by NIH DK52398 , DK080448 , P30 DK046200 ( BNORC ) and the Society for Women’s Health Research, ISIS Foundation . We thank Dr. Karastergiou for careful reading of the manuscript.

PY - 2013/2

Y1 - 2013/2

N2 - Obesity, defined as excess fat mass, increases risks for multiple metabolic diseases, such as type 2 diabetes, cardiovascular disease and several types of cancer. Over and above fat mass per se, the pattern of fat distribution, android or truncal as compared to gynoid or peripheral, has a profound influence on systemic metabolism and hence risk for metabolic diseases. Increases in upper body adipose tissue (visceral and abdominal subcutaneous) confer an independent risk, while the quantity of gluteofemoral adipose tissue is protective. Variations in the capacity of different depots to store and release fatty acids and to produce adipokines are important determinants of fat distribution and its metabolic consequences. Depot differences in cellular composition and physiology, including innervation and blood flow, likely influence their phenotypic properties. A number of lines of evidence also support the idea that adipocytes from different anatomical depots are intrinsically different as a result of genetic or developmental events. In this chapter, we will review the phenotypic characteristics of different adipose depots and mechanisms that link their depot-specific biology to metabolic complications in men and women.

AB - Obesity, defined as excess fat mass, increases risks for multiple metabolic diseases, such as type 2 diabetes, cardiovascular disease and several types of cancer. Over and above fat mass per se, the pattern of fat distribution, android or truncal as compared to gynoid or peripheral, has a profound influence on systemic metabolism and hence risk for metabolic diseases. Increases in upper body adipose tissue (visceral and abdominal subcutaneous) confer an independent risk, while the quantity of gluteofemoral adipose tissue is protective. Variations in the capacity of different depots to store and release fatty acids and to produce adipokines are important determinants of fat distribution and its metabolic consequences. Depot differences in cellular composition and physiology, including innervation and blood flow, likely influence their phenotypic properties. A number of lines of evidence also support the idea that adipocytes from different anatomical depots are intrinsically different as a result of genetic or developmental events. In this chapter, we will review the phenotypic characteristics of different adipose depots and mechanisms that link their depot-specific biology to metabolic complications in men and women.

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KW - RBP4

KW - SAA

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KW - VAT

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KW - free fatty acids

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KW - granulocyte-macrophage colony stimulating factor

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KW - stromal vascular cells

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KW - triacylglyeride

KW - tumor necrosis factor-alpha

KW - very low density lipoprotein

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U2 - 10.1016/j.mam.2012.10.001

DO - 10.1016/j.mam.2012.10.001

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SN - 0098-2997

VL - 34

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EP - 11

JO - Molecular Aspects of Medicine

JF - Molecular Aspects of Medicine

IS - 1

ER -

Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications

Abstract

Keywords

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