TY - JOUR
T1 - Adipose ‘neighborhoods’ collaborate to maintain metabolic health
AU - Fried, Susan K.
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/8
Y1 - 2023/8
N2 - Body fat is stored in anatomically distinct adipose depots that vary in their cell composition and play specialized roles in systemic metabolic homeostasis via secreted products. Their local effects on nearby tissues (e.g. the gut and visceral adipose tissues) are increasingly recognized and this local crosstalk is being elucidated. The major subcutaneous fat depots, abdominal and gluteal–femoral, exert opposite effects on the risk of metabolic disease. The pace of research into developmental, sex, and genetic determinants of human adipose depot growth and function is rapidly accelerating, providing insight into the pathogenesis of metabolic dysfunction in persons with obesity.
AB - Body fat is stored in anatomically distinct adipose depots that vary in their cell composition and play specialized roles in systemic metabolic homeostasis via secreted products. Their local effects on nearby tissues (e.g. the gut and visceral adipose tissues) are increasingly recognized and this local crosstalk is being elucidated. The major subcutaneous fat depots, abdominal and gluteal–femoral, exert opposite effects on the risk of metabolic disease. The pace of research into developmental, sex, and genetic determinants of human adipose depot growth and function is rapidly accelerating, providing insight into the pathogenesis of metabolic dysfunction in persons with obesity.
UR - http://www.scopus.com/inward/record.url?scp=85163951646&partnerID=8YFLogxK
U2 - 10.1016/j.gde.2023.102079
DO - 10.1016/j.gde.2023.102079
M3 - Review article
AN - SCOPUS:85163951646
SN - 0959-437X
VL - 81
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
M1 - 102079
ER -