Adiponectin is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction in patients presenting with chest pain

Erdal Cavusoglu, Cyril Ruwende, Vineet Chopra, Sunitha Yanamadala, Calvin Eng, Luther T. Clark, David J. Pinsky, Jonathan D. Marmur

Research output: Contribution to journalArticlepeer-review

185 Scopus citations

Abstract

Aims: To determine the prognostic value of baseline plasma adiponectin levels in patients with known or suspected coronary artery disease referred for coronary angiography. Methods and results: Adiponectin was measured in 325 male patients with stable angina, troponin-negative unstable angina, and non-ST-segment elevation myocardial infarction (MI) undergoing coronary angiography at a Veterans Administration Medical Center. The patients were then followed prospectively for the occurrence of all-cause mortality, cardiac mortality, and MI. Follow-up data at 24 months were available for 97% of the patients. Adiponectin was the only biomarker to independently predict the individual endpoints of all-cause mortality, cardiac mortality, and MI. The 24-month survival rates for patients in the lower (≤4.431 mg/L), middle (>4.431 and ≤8.008 mg/L), and upper (>8.008 mg/L) tertiles of plasma adiponectin values were 95.0, 90.4, and 83.5%, respectively (P=0.0232 by log-rank test). Furthermore, when patients with chest pain were risk-stratified into those with and without a non-ST-segment elevation acute coronary syndrome (NSTEACS), adiponectin remained an independent predictor of both all-cause mortality and cardiac mortality in the NSTEACS subgroup. Conclusion: In a cohort of male patients undergoing coronary angiography, a single baseline determination of plasma adiponectin is independently predictive of the subsequent risk of death and MI.

Original languageEnglish
Pages (from-to)2300-2309
Number of pages10
JournalEuropean Heart Journal
Volume27
Issue number19
DOIs
StatePublished - Oct 2006
Externally publishedYes

Keywords

  • Adiponectin
  • Biomarker
  • Body mass index
  • IL-10
  • Inflammation
  • Prognosis
  • TIMP-1

Fingerprint

Dive into the research topics of 'Adiponectin is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction in patients presenting with chest pain'. Together they form a unique fingerprint.

Cite this