Adherence to World Cancer Research Fund/American Institute for Cancer Research recommendations and pancreatic cancer risk

Aimee L. Lucas; Francesca Bravi; Paolo Boffetta; Jerry Polesel; Diego Serraino; Carlo La Vecchia; Cristina Bosetti

doi:10.1016/j.canep.2015.10.026

Adherence to World Cancer Research Fund/American Institute for Cancer Research recommendations and pancreatic cancer risk

Aimee L. Lucas, Francesca Bravi, Paolo Boffetta, Jerry Polesel, Diego Serraino, Carlo La Vecchia, Cristina Bosetti

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17 Scopus citations

Abstract

Background: Pancreatic cancer is a leading cause of cancer death. A role of dietary factors in pancreatic carcinogenesis has been suggested. The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) published 8 recommendations for cancer prevention. We evaluated the effect of adherence to the WCRF/AICR recommendations on pancreatic cancer risk. Methods: We operationalized 7 of the 8 WCRF/AICR recommendations to generate a WCRF/AICR score. We examined the association of WCRF/AICR score with pancreatic cancer in data from an Italian case-control study of 326 incident cases and 652 controls. Results: Adherence to WCRF/AICR recommendations was associated with a significantly decreased risk of pancreatic cancer. Using a WCRF/AICR score <3.5 as a reference, the adjusted odds ratio (OR) for a score 3.5-<4 was 0.80 (95% CI 0.49, 1.28), for a score 4-<5 0.54 (95% CI 0.35, 0.82), and for score 5 or more 0.41 (95% CI 0.24, 0.68; p-value for trend 0.0002). The OR for a continuous increment of one unit of the WCRF/AICR score was 0.72 (95% CI 0.60, 0.87). Conclusion: Adherence to the WCRF/AICR recommendations may reduce pancreatic cancer risk.

Original language	English
Pages (from-to)	15-21
Number of pages	7
Journal	Cancer Epidemiology
Volume	40
DOIs	https://doi.org/10.1016/j.canep.2015.10.026
State	Published - 1 Feb 2016

Keywords

American Institute for Cancer Research
Diet
Pancreatic cancer
Risk factors
World Cancer Research Fund

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10.1016/j.canep.2015.10.026

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@article{fdf993f4cdd947dd95b5a20ad3098722,

title = "Adherence to World Cancer Research Fund/American Institute for Cancer Research recommendations and pancreatic cancer risk",

abstract = "Background: Pancreatic cancer is a leading cause of cancer death. A role of dietary factors in pancreatic carcinogenesis has been suggested. The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) published 8 recommendations for cancer prevention. We evaluated the effect of adherence to the WCRF/AICR recommendations on pancreatic cancer risk. Methods: We operationalized 7 of the 8 WCRF/AICR recommendations to generate a WCRF/AICR score. We examined the association of WCRF/AICR score with pancreatic cancer in data from an Italian case-control study of 326 incident cases and 652 controls. Results: Adherence to WCRF/AICR recommendations was associated with a significantly decreased risk of pancreatic cancer. Using a WCRF/AICR score <3.5 as a reference, the adjusted odds ratio (OR) for a score 3.5-<4 was 0.80 (95% CI 0.49, 1.28), for a score 4-<5 0.54 (95% CI 0.35, 0.82), and for score 5 or more 0.41 (95% CI 0.24, 0.68; p-value for trend 0.0002). The OR for a continuous increment of one unit of the WCRF/AICR score was 0.72 (95% CI 0.60, 0.87). Conclusion: Adherence to the WCRF/AICR recommendations may reduce pancreatic cancer risk.",

keywords = "American Institute for Cancer Research, Diet, Pancreatic cancer, Risk factors, World Cancer Research Fund",

author = "Lucas, {Aimee L.} and Francesca Bravi and Paolo Boffetta and Jerry Polesel and Diego Serraino and Vecchia, {Carlo La} and Cristina Bosetti",

note = "Funding Information: This work was supported by a grant of the Fondazione Italiana per la Ricerca sul Cancro (FIRC) , Italy. ALL received support from by grant KL2 TR000069/UL1TR000067 from the National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA. FB was supported by a Fondazione Umberto Veronesi Fellowship, Italy. Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2016",

month = feb,

day = "1",

doi = "10.1016/j.canep.2015.10.026",

language = "English",

volume = "40",

pages = "15--21",

journal = "Cancer Epidemiology",

issn = "1877-7821",

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TY - JOUR

T1 - Adherence to World Cancer Research Fund/American Institute for Cancer Research recommendations and pancreatic cancer risk

AU - Lucas, Aimee L.

AU - Bravi, Francesca

AU - Boffetta, Paolo

AU - Polesel, Jerry

AU - Serraino, Diego

AU - Vecchia, Carlo La

AU - Bosetti, Cristina

N1 - Funding Information: This work was supported by a grant of the Fondazione Italiana per la Ricerca sul Cancro (FIRC) , Italy. ALL received support from by grant KL2 TR000069/UL1TR000067 from the National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA. FB was supported by a Fondazione Umberto Veronesi Fellowship, Italy. Publisher Copyright: © 2015 Elsevier Ltd.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Background: Pancreatic cancer is a leading cause of cancer death. A role of dietary factors in pancreatic carcinogenesis has been suggested. The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) published 8 recommendations for cancer prevention. We evaluated the effect of adherence to the WCRF/AICR recommendations on pancreatic cancer risk. Methods: We operationalized 7 of the 8 WCRF/AICR recommendations to generate a WCRF/AICR score. We examined the association of WCRF/AICR score with pancreatic cancer in data from an Italian case-control study of 326 incident cases and 652 controls. Results: Adherence to WCRF/AICR recommendations was associated with a significantly decreased risk of pancreatic cancer. Using a WCRF/AICR score <3.5 as a reference, the adjusted odds ratio (OR) for a score 3.5-<4 was 0.80 (95% CI 0.49, 1.28), for a score 4-<5 0.54 (95% CI 0.35, 0.82), and for score 5 or more 0.41 (95% CI 0.24, 0.68; p-value for trend 0.0002). The OR for a continuous increment of one unit of the WCRF/AICR score was 0.72 (95% CI 0.60, 0.87). Conclusion: Adherence to the WCRF/AICR recommendations may reduce pancreatic cancer risk.

AB - Background: Pancreatic cancer is a leading cause of cancer death. A role of dietary factors in pancreatic carcinogenesis has been suggested. The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) published 8 recommendations for cancer prevention. We evaluated the effect of adherence to the WCRF/AICR recommendations on pancreatic cancer risk. Methods: We operationalized 7 of the 8 WCRF/AICR recommendations to generate a WCRF/AICR score. We examined the association of WCRF/AICR score with pancreatic cancer in data from an Italian case-control study of 326 incident cases and 652 controls. Results: Adherence to WCRF/AICR recommendations was associated with a significantly decreased risk of pancreatic cancer. Using a WCRF/AICR score <3.5 as a reference, the adjusted odds ratio (OR) for a score 3.5-<4 was 0.80 (95% CI 0.49, 1.28), for a score 4-<5 0.54 (95% CI 0.35, 0.82), and for score 5 or more 0.41 (95% CI 0.24, 0.68; p-value for trend 0.0002). The OR for a continuous increment of one unit of the WCRF/AICR score was 0.72 (95% CI 0.60, 0.87). Conclusion: Adherence to the WCRF/AICR recommendations may reduce pancreatic cancer risk.

KW - American Institute for Cancer Research

KW - Diet

KW - Pancreatic cancer

KW - Risk factors

KW - World Cancer Research Fund

UR - http://www.scopus.com/inward/record.url?scp=84960107823&partnerID=8YFLogxK

U2 - 10.1016/j.canep.2015.10.026

DO - 10.1016/j.canep.2015.10.026

M3 - Article

C2 - 26605429

AN - SCOPUS:84960107823

SN - 1877-7821

VL - 40

SP - 15

EP - 21

JO - Cancer Epidemiology

JF - Cancer Epidemiology

ER -

Adherence to World Cancer Research Fund/American Institute for Cancer Research recommendations and pancreatic cancer risk

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Keywords

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