Adenosine-induced transient asystole for management of a basilar artery aneurysm: Case report

Michael W. Groff, David C. Adams, Ronald A. Kahn, Uday M. Kumbar, Bo Yi Yang, Joshua B. Bederson

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Advances in anesthetic and surgical management, such as induced deep hypothermic circulatory arrest and application of temporary clips, have improved outcome for patients with basilar artery aneurysms. Nonetheless, these techniques are associated with significant risks. The authors report a case in which three transient periods of cardiac asystole were induced during basilar artery aneurysm surgery. Adenosine-induced asystole facilitated the safe clipping of the aneurysm by producing consistent periods of profound hypotension and collapse of the aneurysm without the need for temporary clipping. This technique provided unencumbered identification of perforating arteries, precise definition of the local anatomy, and an ideal environment for the safe placement of the aneurysm clip.

Original languageEnglish
Pages (from-to)687-690
Number of pages4
JournalJournal of Neurosurgery
Issue number4
StatePublished - Oct 1999


  • Adenosine
  • Asystole
  • Basilar artery
  • Cerebral aneurysm
  • Hypotension
  • Pharmacology


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