Adenocarcinoma following ileal pouch-anal anastomosis for ulcerative colitis: Review of 26 cases

Bernardino C. Branco, David B. Sachar, Tomas M. Heimann, Umut Sarpel, Noam Harpaz, Adrian J. Greenstein

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

The occurrence of adenocarcinoma following ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) is an infrequent and but potentially lethal complication. We have seen 1 such case among 520 IPAAs performed in our group practice between 1978 and February 2008. We have added this case to a review of 25 previously reported cases of adenocarcinoma of the pouch or outflow tract following IPAA for UC. Our conclusions are 1) that post-IPAA cancer can occur following either mucosectomy or stapled anastomosis; 2) that this malignancy can occur after IPAA performed for UC either with or without neoplasia; and 3) that this complication is seen whether or not the initial cancer or dysplasia had involved the rectum.

Original languageEnglish
Pages (from-to)295-299
Number of pages5
JournalInflammatory Bowel Diseases
Volume15
Issue number2
DOIs
StatePublished - 2009

Keywords

  • Adenocarcinoma
  • Ileal pouch anal anastomosis (IPAA)
  • Mucosectomy
  • Pouch cancer
  • Stapled anastomosis
  • Ulcerative colitis

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