Additivity in murine circadian phototransduction

John D. Bullough, Mariana G. Figueiro, Bernard P. Possidente, Robert H. Parsons, Mark S. Rea

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Additivity in the circadian phototransduction system of the mouse has not been tested directly. Because of this, accurate prediction of circadian phase shifts elicited by polychromatic light stimuli cannot be derived from the results of studies using monochromatic light stimuli. This limitation also makes it impossible to deduce the relative contributions of the photoreceptive mechanisms (rods, cones and melanopsin-containing retinal ganglion cells) underlying circadian phototransduction in the mouse. Using nearly monochromatic light stimuli of different spectral composition, and combinations thereof, we demonstrated that murine circadian phototransduction exhibits additivity. Based on the locomotor activity phase shifts elicited by these stimuli, we developed the first quantitative assessment of the relative contributions of conventional and novel photoreceptive mechanisms for circadian functioning in the mouse.

Original languageEnglish
Pages (from-to)223-227
Number of pages5
JournalZoological Science
Issue number2
StatePublished - Feb 2005
Externally publishedYes


  • Additivity
  • Circadian rhythms
  • Melanopsin
  • Photoreceptors
  • Spectral opponency


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