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Adding dose modifications into Phase II and Phase II/III seamless trials
John Spivack
, Bin Cheng
, Bruce Levin
Environmental Medicine
Icahn School of Medicine at Mount Sinai
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peer-review
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Keyphrases
Dose Adjustment
100%
Interim Analysis
50%
Dose Selection
50%
Efficiency Improvement
50%
Familywise Error Rate
50%
Strong Control
50%
Adaptive Exploration
50%
Non-monotonic Dose Response
50%
Exploration Strategy
50%
False Declaration
50%
Mathematics
Response Curve
100%
Interim Analysis
100%
Familywise Error Rate
100%
Medicine and Dentistry
Interim Analysis
100%
Dose Response
100%
Agricultural and Biological Sciences
Dose Response
100%