Acute Visual Deficits

Clotilde Hainline, Alexandra Lloyd-Smith, Janet C. Rucker, Madhura A. Tamhankar, Laura J. Balcer

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


In this chapter, we discuss two etiologies of vision loss that often present to the Emergency Department, and the two pivotal, randomized, double-blinded controlled trials that looked into the optimal management of these different etiologies. In the first half of this chapter, we will discuss the Optic Neuritis Treatment Trial, which provided evidence for how best to manage acute optic neuritis, as well as long-term outcomes of therapy. In the second half of this chapter, we will discuss the Idiopathic Intracranial Hypertension Treatment Trial, which provided the first large-scale evidence for medical therapy in treatment of mild vision loss due to idiopathic intracranial hypertension.

Original languageEnglish
Title of host publicationHandbook of Neuroemergency Clinical Trials
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages22
ISBN (Electronic)9780128041017
ISBN (Print)9780128040645
StatePublished - 2018
Externally publishedYes


  • Acetazolamide
  • Clinically isolated syndrome
  • Idiopathic intracranial hypertension
  • Idiopathic intracranial hypertension treatment trial
  • Optic neuritis
  • Optic neuritis treatment trial
  • Pseudotumor cerebri
  • Steroids


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