Acute renal infarction associated with homozygous methylenetetrahydrofolate reductase mutation C677T and IgA beta-2-glycoprotein antibodies

Panagiotis J. Vlachostergios, François Dufresne

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6 Scopus citations

Abstract

Arterial thrombosis of the kidney(s) is a rare clinical entity usually presenting as a result of cardioembolic disease, though rare inherited hypercoagulable states have also been implicated. Within this context, both hyperhomocysteinemia triggered by a mutated methylenetetrahydrofolate reductase (MTHFR) gene product and the presence of antiphospholipid antibodies have been separately associated with arterial thrombotic events, including renal artery embolism. We present a case of combined homozygous MTHFR C677T mutation and IgA beta-2-glycoprotein antibody positivity resulting in acute renal infarction and previous silent myocardial infarction. An acute and otherwise unexplained thrombotic event of unusual location always warrants further investigation, which should include testing for hereditary thrombophilic disorders.

Original languageEnglish
Pages (from-to)583-585
Number of pages3
JournalBlood Coagulation and Fibrinolysis
Volume26
Issue number5
DOIs
StatePublished - 10 Jul 2015
Externally publishedYes

Keywords

  • antiphospholipid antibodies
  • hypercoagulable
  • hyperhomocysteinemia
  • methylenetetrahydrofolate reductase mutation
  • renal artery thrombosis
  • renal infarction
  • thrombophilia

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