Acute Renal Failure in Kidney Transplant Recipients

Paolo Cravedi, Madhav Menon, Norberto Perico, Giuseppe Remuzzi

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Delayed graft function (DGF) is a form of acute renal failure of kidney transplantation resulting in post-transplant oliguria, increased allograft immunogenicity and risk of acute rejection. Rarely, the graft never functions this leading to primary non-function. Experimental studies have shown that both ischemia and reinstitution of blood flow in ischemically damaged kidneys after hypothermic preservation activate a complex sequence of events that sustain renal injury and play a pivotal role in the development of DGF (1). Quality of donor grafts, organ preservation technique, and choice of early immunosppression are key determinants of DGF that will be discussed herein.

Original languageEnglish
Title of host publicationCritical Care Nephrology
Subtitle of host publicationThird Edition
PublisherElsevier Inc.
Number of pages7
ISBN (Electronic)9780323449427
ISBN (Print)9780323449427
StatePublished - 6 Dec 2017


  • Acute kidney injury
  • Acute rejection
  • Delayed graft function (DGF)
  • Ischemia-reperfusion injury
  • Long-term graft survival


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