Acute Renal Failure Associated With Ioxaglate, a Low-Osmolality Radiocontrast Agent

Narcis B. Aron, Donald A. Feinfeld, Alexandra T. Peters, Robert I. Lynn

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23 Scopus citations


Iodinated radiocontrast agents may cause acute renal failure, particularly in patients with preexisting renal failure, heart failure, or diabetes. The low-osmolality contrast agents cause less hypersensitivity, but substantial nephrotoxicity has not been noted. We report three high-risk patients who developed acute renal failure after one of these new agents, ioxaglate, was administered for coronary arteriography and ventriculography. The renal failure was severe: two of the patients required dialysis. We could find no previously reported cases of acute renal failure associated with ioxaglate. Despite their theoretical advantages, the low-osmolality contrast agents may cause acute renal failure in patients who are at risk and should be used with the same precautions as the conventional agents.

Original languageEnglish
Pages (from-to)189-193
Number of pages5
JournalAmerican Journal of Kidney Diseases
Issue number3
StatePublished - 1989
Externally publishedYes


  • Radiocontrast agents
  • acute renal failure
  • diabetes mellitus
  • heart failure
  • ioxaglate
  • osmolality


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