Acute nonlymphocytic leukemia following gastric adenocarcinoma treated by surgery alone evidence for etiologic heterogeneity of “secondary” leukemias

Alexander Haubenstock; Ralph Zalusky; Stephanie Seremetis; Hyon Ju Kim; Stephen C. Malamud; Mary Ann Perle; Joseph H. Pipala; David H. Witt

doi:10.1002/1097-0142(19851015)56:8<2069::AID-CNCR2820560830>3.0.CO;2-4

Acute nonlymphocytic leukemia following gastric adenocarcinoma treated by surgery alone evidence for etiologic heterogeneity of “secondary” leukemias

Alexander Haubenstock
, Ralph Zalusky
, Stephanie Seremetis
, Hyon Ju Kim
, Stephen C. Malamud
, Mary Ann Perle
, Joseph H. Pipala
, David H. Witt

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The case of a 36‐year‐old Hispanic man who developed acute nonlymphocytic leukemia 18 months following gastric adenocarcinoma treated by surgery alone is presented. Cytogenetic analysis of the leukemic cells revealed numerical and structural chromosomal rearrangements including chromosomes 5 and 7 and immunologic characterization of the blasts revealed terminal deoxynucleotidyltransferase positivity with monocytoid features. This report suggests that not all cases of acute nonlymphocytic leukemia following chemotherapy and/or radiotherapy, which characteristically display similar cytogenetic and immunologic features, should be exclusively ascribed to the leukemogenic properties of anticancer treatment. Cancer 56: 2069‐2073, 1985.

Original language	English
Pages (from-to)	2069-2073
Number of pages	5
Journal	Cancer
Volume	56
Issue number	8
DOIs	https://doi.org/10.1002/1097-0142(19851015)56:8<2069::AID-CNCR2820560830>3.0.CO;2-4
State	Published - 15 Oct 1985
Externally published	Yes

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10.1002/1097-0142(19851015)56:8<2069::AID-CNCR2820560830>3.0.CO;2-4

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Haubenstock, A., Zalusky, R., Seremetis, S., Kim, H. J., Malamud, S. C., Perle, M. A., Pipala, J. H., & Witt, D. H. (1985). Acute nonlymphocytic leukemia following gastric adenocarcinoma treated by surgery alone evidence for etiologic heterogeneity of “secondary” leukemias. Cancer, 56(8), 2069-2073. https://doi.org/10.1002/1097-0142(19851015)56:8<2069::AID-CNCR2820560830>3.0.CO;2-4

@article{8ad94be0b3ac4edab05c124a3c43cef2,

title = "Acute nonlymphocytic leukemia following gastric adenocarcinoma treated by surgery alone evidence for etiologic heterogeneity of {\textquotedblleft}secondary{\textquotedblright} leukemias",

abstract = "The case of a 36‐year‐old Hispanic man who developed acute nonlymphocytic leukemia 18 months following gastric adenocarcinoma treated by surgery alone is presented. Cytogenetic analysis of the leukemic cells revealed numerical and structural chromosomal rearrangements including chromosomes 5 and 7 and immunologic characterization of the blasts revealed terminal deoxynucleotidyltransferase positivity with monocytoid features. This report suggests that not all cases of acute nonlymphocytic leukemia following chemotherapy and/or radiotherapy, which characteristically display similar cytogenetic and immunologic features, should be exclusively ascribed to the leukemogenic properties of anticancer treatment. Cancer 56: 2069‐2073, 1985.",

author = "Alexander Haubenstock and Ralph Zalusky and Stephanie Seremetis and Kim, \{Hyon Ju\} and Malamud, \{Stephen C.\} and Perle, \{Mary Ann\} and Pipala, \{Joseph H.\} and Witt, \{David H.\}",

year = "1985",

month = oct,

day = "15",

doi = "10.1002/1097-0142(19851015)56:8<2069::AID-CNCR2820560830>3.0.CO;2-4",

language = "English",

volume = "56",

pages = "2069--2073",

journal = "Cancer",

issn = "0008-543X",

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}

Haubenstock, A, Zalusky, R, Seremetis, S, Kim, HJ, Malamud, SC, Perle, MA, Pipala, JH & Witt, DH 1985, 'Acute nonlymphocytic leukemia following gastric adenocarcinoma treated by surgery alone evidence for etiologic heterogeneity of “secondary” leukemias', Cancer, vol. 56, no. 8, pp. 2069-2073. https://doi.org/10.1002/1097-0142(19851015)56:8<2069::AID-CNCR2820560830>3.0.CO;2-4

TY - JOUR

T1 - Acute nonlymphocytic leukemia following gastric adenocarcinoma treated by surgery alone evidence for etiologic heterogeneity of “secondary” leukemias

AU - Haubenstock, Alexander

AU - Zalusky, Ralph

AU - Seremetis, Stephanie

AU - Kim, Hyon Ju

AU - Malamud, Stephen C.

AU - Perle, Mary Ann

AU - Pipala, Joseph H.

AU - Witt, David H.

PY - 1985/10/15

Y1 - 1985/10/15

N2 - The case of a 36‐year‐old Hispanic man who developed acute nonlymphocytic leukemia 18 months following gastric adenocarcinoma treated by surgery alone is presented. Cytogenetic analysis of the leukemic cells revealed numerical and structural chromosomal rearrangements including chromosomes 5 and 7 and immunologic characterization of the blasts revealed terminal deoxynucleotidyltransferase positivity with monocytoid features. This report suggests that not all cases of acute nonlymphocytic leukemia following chemotherapy and/or radiotherapy, which characteristically display similar cytogenetic and immunologic features, should be exclusively ascribed to the leukemogenic properties of anticancer treatment. Cancer 56: 2069‐2073, 1985.

AB - The case of a 36‐year‐old Hispanic man who developed acute nonlymphocytic leukemia 18 months following gastric adenocarcinoma treated by surgery alone is presented. Cytogenetic analysis of the leukemic cells revealed numerical and structural chromosomal rearrangements including chromosomes 5 and 7 and immunologic characterization of the blasts revealed terminal deoxynucleotidyltransferase positivity with monocytoid features. This report suggests that not all cases of acute nonlymphocytic leukemia following chemotherapy and/or radiotherapy, which characteristically display similar cytogenetic and immunologic features, should be exclusively ascribed to the leukemogenic properties of anticancer treatment. Cancer 56: 2069‐2073, 1985.

UR - https://www.scopus.com/pages/publications/0021965401

U2 - 10.1002/1097-0142(19851015)56:8<2069::AID-CNCR2820560830>3.0.CO;2-4

DO - 10.1002/1097-0142(19851015)56:8<2069::AID-CNCR2820560830>3.0.CO;2-4

M3 - Article

C2 - 3896466

AN - SCOPUS:0021965401

SN - 0008-543X

VL - 56

SP - 2069

EP - 2073

JO - Cancer

JF - Cancer

IS - 8

ER -

Acute nonlymphocytic leukemia following gastric adenocarcinoma treated by surgery alone evidence for etiologic heterogeneity of “secondary” leukemias

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