Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus

Paul J. Kenny, Sandra E. File, Marcus Rattray

Research output: Contribution to journalArticlepeer-review

137 Scopus citations

Abstract

Acute nicotine administration (0.5 mg/kg i.p.) significantly decreased BDNF mRNA levels in dentate gyrus, CA3 and CA1 subfields of the rat hippocampus 2 h and 24 h after administration. However, with 7 days nicotine treatment, tolerance developed to the inhibitory effect of nicotine on BDNF mRNA expression and there was a significant increase in BDNF expression 2 h after the final injection in the CA1 region. These data suggests that changes in expression of hippocampal BDNF may be involved in the behavioural effects of nicotine observed after acute and chronic treatment.

Original languageEnglish
Pages (from-to)234-238
Number of pages5
JournalMolecular Brain Research
Volume85
Issue number1-2
DOIs
StatePublished - 28 Dec 2000
Externally publishedYes

Keywords

  • Acetylcholine
  • Drug dependence
  • In situ hybridisation
  • Neurotrophin
  • Withdrawal

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