@article{d418af2ff4f843d586b900bc0f651536,
title = "Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells",
abstract = "Wesely et al. report that AML-iPSC-derived hematopoietic cells are hierarchically organized and contain cells with hallmark features of LSCs (iLSCs). Through integrative genomic studies of bulk and single-cell transcriptomes and chromatin accessibility, they derive a LSC gene signature and identify RUNX1 as an AML LSC dependency with therapeutic implications.",
keywords = "AML, LSC gene signature, Leukemia stem cells, RUNX1, iLSCs, iPSCs",
author = "Josephine Wesely and Kotini, {Andriana G.} and Franco Izzo and Hanzhi Luo and Han Yuan and Jun Sun and Maria Georgomanoli and Asaf Zviran and Deslauriers, {Andr{\'e} G.} and Neville Dusaj and Nimer, {Stephen D.} and Christina Leslie and Landau, {Dan A.} and Kharas, {Michael G.} and Papapetrou, {Eirini P.}",
note = "Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = jun,
day = "2",
doi = "10.1016/j.celrep.2020.107688",
language = "English",
volume = "31",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "9",
}