Acute myeloid leukemia

Kevin Barley, Shyamala C. Navada

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Acute myeloid leukemia (AML) is an aggressive, rare, and heterogeneous neoplasm that can occur de novo or secondary to a preceding MDS or MPN. Risk stratification and treatment decisions are based upon age, performance status, and genetic abnormalities. Current management options include aggressive supportive care, intensive chemotherapy, hypomethylating agents, and hematopoietic stem cell transplantation. Relapse rates and mortality remain high. Current research is focused on improved prognostication and risk stratification as well as the development of novel therapeutics. Targeted agents directed towards specific genetic mutations in AML are currently in clinical trials and early results are promising.

Original languageEnglish
Title of host publicationOncology
Publisherwiley
Pages308-318
Number of pages11
ISBN (Electronic)9781119189596
ISBN (Print)9781119189558
DOIs
StatePublished - 30 Aug 2019

Keywords

  • Acute myeloid leukemia
  • Acute promyelocytic leukemia
  • Azacitidine
  • Cytarabine
  • Daunorubicin
  • Decitabine
  • Idarubicin

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