Acute lymphoblastic leukemia

Jaclyn C. Davis, Birte Wistinghausen

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood but is rare in adults. Great strides have been made in the treatment and cure of children with ALL, with 80-90% of pediatric patients being cured with combination chemotherapy. Cure rates for adults and certain subgroups with adverse risk factors are significantly lower. Improved recognition of risk factors such as early response to therapy has led to improved risk classifications and tailored treatment strategies. For patients with poor prognosis, bone marrow transplant may be indicated and new treatment strategies including bidirectional T-cell engagers and cellular therapies are currently in clinical trials.

Original languageEnglish
Title of host publicationOncology
Publisherwiley
Pages319-331
Number of pages13
ISBN (Electronic)9781119189596
ISBN (Print)9781119189558
DOIs
StatePublished - 30 Aug 2019
Externally publishedYes

Keywords

  • Acute lymphoblastic leukemia
  • Adults
  • Childhood
  • Risk classification

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