Acute leukemia as a complication of cytotoxic chemotherapy

Fred Rosner, Hans W. Grünwald, M. Hosein Zarrabi

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Acute leukemia occurring after intensive cytotoxic chemotherapy and/or radiotherapy has been reported in 122 patients with multiple myeloma, in 93 patients with Hodgkin's disease, in 78 patients with breast cancer, in 45 patients with non-Hodgkin's lymphoma, in 41 patients with chronic lymphotic leukemia and in 61 patients receiving immunosuppressive chemotherapy for a variety of non-neoplastic diseases. Although risk estimates have been calculated for several large series of patients (approximately 1% to 3% in several series), the precise carcinogenic or leukemogenic potential of cancer chemotherapeutic agents singly and in combinations is not known.

Original languageEnglish
Pages (from-to)1705-1707
Number of pages3
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number9
StatePublished - Sep 1979
Externally publishedYes


  • Acute leukemia
  • Cytotoxic chemotherapy
  • Review of literature


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