TY - JOUR
T1 - Acute kidney injury genetic risks
T2 - taking it 1 SNP at a time
AU - Himmelfarb, Jonathan
AU - Stanaway, Ian B.
AU - Bhatraju, Pavan K.
N1 - Publisher Copyright:
© 2024 International Society of Nephrology
PY - 2024/8
Y1 - 2024/8
N2 - This commentary addresses some of the strengths, shortcomings, and challenges of the genome-wide association study of acute kidney injury (AKI) report in this issue. This AKI genome-wide association study is well executed and provides significant progress in finding 2 genome-wide significant loci. However, significant interpretive challenges remain, where advancements in methods are needed because of the clinical heterogeneity of the AKI phenotype, plus possible bias due to genetic correlation between index hospitalization risk and AKI risk.
AB - This commentary addresses some of the strengths, shortcomings, and challenges of the genome-wide association study of acute kidney injury (AKI) report in this issue. This AKI genome-wide association study is well executed and provides significant progress in finding 2 genome-wide significant loci. However, significant interpretive challenges remain, where advancements in methods are needed because of the clinical heterogeneity of the AKI phenotype, plus possible bias due to genetic correlation between index hospitalization risk and AKI risk.
UR - http://www.scopus.com/inward/record.url?scp=85197796308&partnerID=8YFLogxK
U2 - 10.1016/j.kint.2024.05.011
DO - 10.1016/j.kint.2024.05.011
M3 - Comment/debate
C2 - 39032964
AN - SCOPUS:85197796308
SN - 0085-2538
VL - 106
SP - 188
EP - 190
JO - Kidney International
JF - Kidney International
IS - 2
ER -