Acute kidney injury genetic risks: taking it 1 SNP at a time

Jonathan Himmelfarb, Ian B. Stanaway, Pavan K. Bhatraju

Research output: Contribution to journalComment/debate

Abstract

This commentary addresses some of the strengths, shortcomings, and challenges of the genome-wide association study of acute kidney injury (AKI) report in this issue. This AKI genome-wide association study is well executed and provides significant progress in finding 2 genome-wide significant loci. However, significant interpretive challenges remain, where advancements in methods are needed because of the clinical heterogeneity of the AKI phenotype, plus possible bias due to genetic correlation between index hospitalization risk and AKI risk.

Original languageEnglish
Pages (from-to)188-190
Number of pages3
JournalKidney International
Volume106
Issue number2
DOIs
StatePublished - Aug 2024

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