Acute hyperglycemic syndromes: Diabetic ketoacidosis and the hyperosmolar state

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The patient, often a "repeat offender" who stops taking insulin, presents with increasing urination and thirst along with nausea, vomiting, abdominal pain, dehydration, weakness, and dizziness. The patient may become confused and slip into coma. The respiratory compensation that accompanies acidemia causes deep rapid (Kussmaul) breathing. The sweet smell of the volatile ketone body acetone signals the possibility of ketoacidosis. The treating physician seeks to reestablish normal physiology and restore the patient to normal function. Thankfully, treatment is remarkably straightforward and involves intravenous fluid, insulin, potassium, and vigilance.

Original languageEnglish
Title of host publicationPrinciples of Diabetes Mellitus
Subtitle of host publicationThird Edition
PublisherSpringer International Publishing
Pages349-365
Number of pages17
ISBN (Electronic)9783319187419
ISBN (Print)9783319187402
DOIs
StatePublished - 7 Jul 2017

Keywords

  • Acetoacetate
  • Anion gap metabolic acidosis
  • Cerebral edema
  • Diabetic ketoacidosis
  • Free fatty acids
  • Hyperglycemia
  • Hyperosmolar hyperglycemia syndrome
  • Ketosis
  • Kussmaul
  • Type 1 diabetes
  • Type 2 diabetes
  • β-hydroxybutyrate

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