Acute hepatitis B virus infection by genotype F despite successful vaccination in an immune-competent German patient

Frank Tacke, Samad Amini-Bavil-Olyaee, Albert Heim, Tom Luedde, Michael P. Manns, Christian Trautwein

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Background: : Hepatitis B Virus (HBV) infection is a leading cause of chronic hepatitis and liver cirrhosis worldwide, and efficient protection can usually be achieved by vaccination that is based on recombinant HBsAg protein from HBV genotype A and D. Results: : Here we report the case of a fully immune-competent German patient that acquired a symptomatic acute HBV infection during adulthood despite a complete and formally successful vaccination, which had resulted in anti-HBs titers considered protective. Further phylogentic analysis identified an infection with the rare genotype F of HBV, possibly acquired in Spain, without apparent aberrations in the immunodominant 'a' determinant domain of the envelope gene. However, sequence comparisons revealed that all reported genotype F isolates display marked differences from the other genotypes in this domain which serves as an epitope for humoral immune responses. Conclusions: : The rare HBV genotype F, as detected in this immune-competent, previously vaccinated patient, has marked sequences differences in the envelope/polymerase gene. Therefore, current HBV vaccines based on genotype A and D may not result in full protective immunity towards viral strains from genotype F.

Original languageEnglish
Pages (from-to)353-357
Number of pages5
JournalJournal of Clinical Virology
Volume38
Issue number4
DOIs
StatePublished - Apr 2007
Externally publishedYes

Keywords

  • A-determinant region
  • Antigenicity
  • Escape mutant
  • Genotype
  • HBV DNA
  • Hepatitis B Virus

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