Acute graft-versus-host disease following lung transplantation in a patient with a novel TERT mutation

Jonathan R. Brestoff, Alexandre T. Vessoni, Kirsten A. Brenner, Geoffrey L. Uy, John F. DiPersio, Morey Blinder, Chad A. Witt, Derek E. Byers, Ramsey R. Hachem, Elbert P. Truclock, Dayna S. Early, Milan J. Anadkat, Amy Musiek, Cylen Javidan-Nejad, Dennis M. Balfe, Ilana S. Rosman, Chang Liu, Lingxin Zhang, George J. Despotis, Marianna B. RuzinovaJennifer K. Sehn, Ina Amarillo, Jonathan W. Heusel, Wojcieh Swat, Brian S. Kim, Lukas D. Wartman, Roger D. Yusen, Luis F.Z. Batista

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Familial pulmonary fibrosis is associated with loss-of-function mutations in telomerase reverse transcriptase (TERT) and short telomeres. Interstitial lung diseases have become the leading indication for lung transplantation in the USA, and recent data indicate that pathogenic mutations in telomerase may cause unfavourable outcomes following lung transplantation. Although a rare occurrence, solid organ transplant recipients who develop acute graft-versus-host disease (GVHD) have very poor survival. This case report describes the detection of a novel mutation in TERT in a patient who had lung transplantation for familial pulmonary fibrosis and died from complications of acute GVHD.

Original languageEnglish
Pages (from-to)489-492
Number of pages4
JournalThorax
Volume73
Issue number5
DOIs
StatePublished - 1 May 2018
Externally publishedYes

Keywords

  • airway epithelium
  • idiopathic pulmonary fibrosis

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