Abstract
To evaluate the effects of ethanol in the human brain, we tested six normal subjects and six alcoholics using positron emission tomography and 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) under baseline conditions and 24 hours later after ethanol administration (1 g/kg). Ethanol inhibited cortical and cerebellar glucose metabolism with relative sparing of the basal ganglia and corpus callosum. This inhibition was more pronounced in the alcoholics than in the controls. Measurement of the constants for glucose transport and utilization showed that decreased glucose metabolism was due to a reduction in glucose phosphorylation and not to a change of glucose transport into the tissue. The pattern of regional metabolic inhibition by alcohol paralleled the distribution of benzodiazepine receptors in the human brain.
Original language | English |
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Pages (from-to) | 39-48 |
Number of pages | 10 |
Journal | Psychiatry Research - Neuroimaging |
Volume | 35 |
Issue number | 1 |
DOIs | |
State | Published - Apr 1990 |
Externally published | Yes |
Keywords
- Ethanol
- F-fluorodeoxyglucose
- benzodiazepine receptors
- positron emission tomography