Acute coronary syndromes without coronary plaque rupture

Siddak S. Kanwar, Gregg W. Stone, Mandeep Singh, Renu Virmani, Jeffrey Olin, Takashi Akasaka, Jagat Narula

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

The latest advances in plaque imaging have provided clinicians with opportunities to treat acute coronary syndrome (ACS) and provide individualized treatment recommendations based not only on clinical manifestations, angiographic characteristics, and biomarker data, but also on the findings of plaque morphology. Although a substantial proportion of ACS events originate from plaques with an intact fibrous cap (IFC), clinicians predominantly equate ACS with plaque rupture arising from thin-cap fibroatheromas. In this Review, we discuss the recent advances in our understanding of plaque morphology in ACS with IFC, reviewing contemporary data from intravascular imaging. We also explore whether use of such imaging might provide a roadmap for more effective management of patients with ACS.

Original languageEnglish
Pages (from-to)257-265
Number of pages9
JournalNature Reviews Cardiology
Volume13
Issue number5
DOIs
StatePublished - 1 May 2016

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