Acute coronary syndrome

Brandon W. Calenda, Umesh K. Gidwani

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Acute coronary syndrome (ACS) is a common and sometimes lethal event, usually precipitated by sudden rupture and thrombosis of an atherosclerotic plaque. Patients presenting with ACS can be rapidly risk stratified based on signs, symptoms, electrocardiogram, and biomarkers. There is a new generation of potent and reliable antiplatelet drugs, which in concert with anticoagulation and rapid revascularization, can preserve myocardium and save lives. When choosing how to revascularize, hemodynamically stable patients with diabetes mellitus and complex coronary disease benefit more from coronary artery bypass grafting rather than percutaneous coronary intervention. Despite optimal treatment, ACS can result in deadly complications such as cardiogenic shock. Supportive care is paramount, but despite its widespread use, the utility of intraaortic balloon counterpulsation is uncertain. In the future, advanced coronary imaging may enhance preventative care, novel molecular targets will help expand treatment options, and cell-based regenerative therapies may aid myocardial recovery after acute coronary syndrome.

Original languageEnglish
Title of host publicationModern Concepts and Practices in Cardiothoracic Critical Care
PublisherIGI Global
Number of pages32
ISBN (Electronic)9781466686045
ISBN (Print)1466686030, 9781466686038
StatePublished - 1 Aug 2015


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