TY - JOUR
T1 - Acute conformational changes in the optic nerve head with rapid intraocular pressure elevation
T2 - Implications for LASIK surgery
AU - Piette, Scott
AU - Liebmann, Jeffrey M.
AU - Ishikawa, Hiroshi
AU - Gürses-Özden, Rabia
AU - Buxton, Douglas
AU - Ritch, Robert
PY - 2003/7
Y1 - 2003/7
N2 - BACKGROUND AND OBJECTIVE: To investigate the effects of acute intraocular pressure (IOP) elevation on optic disc morphology. PATIENTS AND METHODS: Ophthalmodynamometry was used to increase the IOP of normal, healthy eyes. Confocal scanning laser ophthalmoscopy of the optic nerve head using the Heidelberg Retinal Tomograph II (Heidelberg GmbH, Heidelberg, Germany) and IOP measurements were obtained before, during, and after IOP elevation. RESULTS: Sixteen eyes of 16 normal volunteers (mean age, 32.8 ± 11.9 years) were enrolled. Rim area, rim volume, cup area, cup volume, cup-to-disc ratio, mean cup depth, maximum cup depth, mean retinal nerve fiber layer (RNFL) thickness, and RNFL cross-sectional area showed significant changes during IOP elevation (all P < .05, paired t test). All measured parameters returned to their original values after pressure resolution (all P > .2) except mean RNFL thickness (P = .03). CONCLUSION: Transient elevation of IOP results in measurable alterations in optic nerve head topography.
AB - BACKGROUND AND OBJECTIVE: To investigate the effects of acute intraocular pressure (IOP) elevation on optic disc morphology. PATIENTS AND METHODS: Ophthalmodynamometry was used to increase the IOP of normal, healthy eyes. Confocal scanning laser ophthalmoscopy of the optic nerve head using the Heidelberg Retinal Tomograph II (Heidelberg GmbH, Heidelberg, Germany) and IOP measurements were obtained before, during, and after IOP elevation. RESULTS: Sixteen eyes of 16 normal volunteers (mean age, 32.8 ± 11.9 years) were enrolled. Rim area, rim volume, cup area, cup volume, cup-to-disc ratio, mean cup depth, maximum cup depth, mean retinal nerve fiber layer (RNFL) thickness, and RNFL cross-sectional area showed significant changes during IOP elevation (all P < .05, paired t test). All measured parameters returned to their original values after pressure resolution (all P > .2) except mean RNFL thickness (P = .03). CONCLUSION: Transient elevation of IOP results in measurable alterations in optic nerve head topography.
UR - http://www.scopus.com/inward/record.url?scp=0038264046&partnerID=8YFLogxK
M3 - Article
C2 - 12875468
AN - SCOPUS:0038264046
SN - 1542-8877
VL - 34
SP - 334
EP - 341
JO - Ophthalmic Surgery Lasers and Imaging
JF - Ophthalmic Surgery Lasers and Imaging
IS - 4
ER -