Acute Cerebellitis and Myeloradiculitis Associated With SARS-CoV-2 Infection in Common Variable Immunodeficiency—A Case Report

Hernan Nicolas Lemus, Miryam Alkayyali, Eonjung Kim, Charlotte Cunnigham-Rundles, Dewitt Pyburn, Rory Abrams

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The role of the adaptive immune system in mediating COVID-19 is largely unknown. Therefore, it is difficult to predict the clinical course in patients with common variable immunodeficiency (CVID), a disease characterized by dysfunctional lymphocytes and impaired antibody production. We report a case of SARS-CoV-2 infection presenting as isolated neurological symptoms in a patient with CVID. The patient subsequently improved following steroids, intravenous immunoglobulin, and convalescent plasma (CP). The latter has been shown to be safe and efficacious in treating COVID-19 in patients with primary immunodeficiency. Recent data suggest that the mechanism of CNS injury in COVID-19 may be due to immunological dysregulation rather than direct viral-mediated injury. This case exemplifies the complex interaction between the brain, the immune system, and the SARS-CoV-2 virus.

Original languageEnglish
Pages (from-to)361-365
Number of pages5
JournalThe Neurohospitalist
Volume12
Issue number2
DOIs
StatePublished - Apr 2022

Keywords

  • COVID-19
  • cerebellar
  • coronavirus
  • immunocompromised
  • radiculopathy

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