Acute Biventricular Failure as a Sequela of Multiple Autoimmune Disorders

In this case, uncharacteristic clinical and laboratory findings led to an unanticipated diagnosis for a 24-year-old woman admitted for new-onset heart failure with features suggesting cardiac tamponade. Concomitant diagnosis of progressive mixed connective tissue disease associated with severe hypothyroidism was made. Despite early recognition (based on clinical and pathologic features) and rapid management (with glucocorticoids, thyroxine, metoprolol, lisinopril, furosemide, and milrinone), she deteriorated and died within 4 weeks.