Acute allograft injury after kidney transplantation

Bernd Schröppel, Christophe Legendre

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

In as many as 50 % of cases, the immediate post-kidney transplant course is complicated by early kidney dysfunction most commonly related to ischemia and reperfusion injury. This acute kidney injury (AKI) is modulated by a complex interplay of multiple donor and recipient factors. Challenges to understand its mechanisms include the complex interplay of contributors derived from the donor as well as the recipient and lead to hypoxic and ischemic injury as well as altered repair mechanisms. New therapies mainly seek to suppress inflammation, limit cell death, and/or interrupt detrimental signaling of necrosis. While there are several promising novel targets and novel therapeutics available, many challenges remain in the translation from bench to bedside.

Original languageEnglish
Title of host publicationPerioperative Kidney Injury
Subtitle of host publicationPrinciples of Risk Assessment, Diagnosis and Treatment
PublisherSpringer New York
Pages185-195
Number of pages11
ISBN (Electronic)9781493912735
ISBN (Print)9781493912728
DOIs
StatePublished - 1 Jan 2015
Externally publishedYes

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