Abstract
In as many as 50 % of cases, the immediate post-kidney transplant course is complicated by early kidney dysfunction most commonly related to ischemia and reperfusion injury. This acute kidney injury (AKI) is modulated by a complex interplay of multiple donor and recipient factors. Challenges to understand its mechanisms include the complex interplay of contributors derived from the donor as well as the recipient and lead to hypoxic and ischemic injury as well as altered repair mechanisms. New therapies mainly seek to suppress inflammation, limit cell death, and/or interrupt detrimental signaling of necrosis. While there are several promising novel targets and novel therapeutics available, many challenges remain in the translation from bench to bedside.
Original language | English |
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Title of host publication | Perioperative Kidney Injury |
Subtitle of host publication | Principles of Risk Assessment, Diagnosis and Treatment |
Publisher | Springer New York |
Pages | 185-195 |
Number of pages | 11 |
ISBN (Electronic) | 9781493912735 |
ISBN (Print) | 9781493912728 |
DOIs | |
State | Published - 1 Jan 2015 |
Externally published | Yes |