Acute 17β-estradiol treatment down-regulates serotonin 5HT(1A) receptor mRNA expression in the limbic system of female rats

Marie K. Österlund; Yasmin L. Hurd

doi:10.1016/S0169-328X(98)00018-7

Acute 17β-estradiol treatment down-regulates serotonin 5HT(1A) receptor mRNA expression in the limbic system of female rats

Marie K. Österlund, Yasmin L. Hurd

Research output: Contribution to journal › Article › peer-review

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Abstract

In situ hybridization histochemistry was used to investigate acute estrogen effects on serotonin 5HT(1A) receptor mRNA levels in limbic-related brain areas in the female ovariectomized rat. Acute administration of 17β-estradiol (10 μg) decreased 5HT(1A) receptor mRNA expression levels within the medial amygdala (after 2 and 24 h), piriform cortex (after 2 and 24 h), and perirhinal cortex (after 24 h). No changes in 5HT(1A) mRNA levels were observed in hippocampus or retrosplenial cortex. The findings suggest specific regional effects of estrogen on 5HT functions mediated through regulation of the 5HT(1A) gene.

Original language	English
Pages (from-to)	169-172
Number of pages	4
Journal	Molecular Brain Research
Volume	55
Issue number	1
DOIs	https://doi.org/10.1016/S0169-328X(98)00018-7
State	Published - 30 Mar 1998
Externally published	Yes

Keywords

Brain
Depression
Estrogen
In situ hybridization
Serotonin receptor
Steroid hormone

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10.1016/S0169-328X(98)00018-7

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title = "Acute 17β-estradiol treatment down-regulates serotonin 5HT(1A) receptor mRNA expression in the limbic system of female rats",

abstract = "In situ hybridization histochemistry was used to investigate acute estrogen effects on serotonin 5HT(1A) receptor mRNA levels in limbic-related brain areas in the female ovariectomized rat. Acute administration of 17β-estradiol (10 μg) decreased 5HT(1A) receptor mRNA expression levels within the medial amygdala (after 2 and 24 h), piriform cortex (after 2 and 24 h), and perirhinal cortex (after 24 h). No changes in 5HT(1A) mRNA levels were observed in hippocampus or retrosplenial cortex. The findings suggest specific regional effects of estrogen on 5HT functions mediated through regulation of the 5HT(1A) gene.",

keywords = "Brain, Depression, Estrogen, In situ hybridization, Serotonin receptor, Steroid hormone",

author = "{\"O}sterlund, {Marie K.} and Hurd, {Yasmin L.}",

note = "Funding Information: We thank Mrs. Siv Eriksson and Mrs. Barbro Berthelson for technical assistance. This work was supported by grants from the Stiftelsen S{\"o}derstr{\"o}m K{\"o}nigska Sjukhemmet, Fredrik och Ingrid Thurings Stiftelse, and Kapten Arthur Erikssons Stiftelse. ",

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doi = "10.1016/S0169-328X(98)00018-7",

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pages = "169--172",

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T1 - Acute 17β-estradiol treatment down-regulates serotonin 5HT(1A) receptor mRNA expression in the limbic system of female rats

AU - Österlund, Marie K.

AU - Hurd, Yasmin L.

N1 - Funding Information: We thank Mrs. Siv Eriksson and Mrs. Barbro Berthelson for technical assistance. This work was supported by grants from the Stiftelsen Söderström Königska Sjukhemmet, Fredrik och Ingrid Thurings Stiftelse, and Kapten Arthur Erikssons Stiftelse.

PY - 1998/3/30

Y1 - 1998/3/30

N2 - In situ hybridization histochemistry was used to investigate acute estrogen effects on serotonin 5HT(1A) receptor mRNA levels in limbic-related brain areas in the female ovariectomized rat. Acute administration of 17β-estradiol (10 μg) decreased 5HT(1A) receptor mRNA expression levels within the medial amygdala (after 2 and 24 h), piriform cortex (after 2 and 24 h), and perirhinal cortex (after 24 h). No changes in 5HT(1A) mRNA levels were observed in hippocampus or retrosplenial cortex. The findings suggest specific regional effects of estrogen on 5HT functions mediated through regulation of the 5HT(1A) gene.

AB - In situ hybridization histochemistry was used to investigate acute estrogen effects on serotonin 5HT(1A) receptor mRNA levels in limbic-related brain areas in the female ovariectomized rat. Acute administration of 17β-estradiol (10 μg) decreased 5HT(1A) receptor mRNA expression levels within the medial amygdala (after 2 and 24 h), piriform cortex (after 2 and 24 h), and perirhinal cortex (after 24 h). No changes in 5HT(1A) mRNA levels were observed in hippocampus or retrosplenial cortex. The findings suggest specific regional effects of estrogen on 5HT functions mediated through regulation of the 5HT(1A) gene.

KW - Brain

KW - Depression

KW - Estrogen

KW - In situ hybridization

KW - Serotonin receptor

KW - Steroid hormone

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AN - SCOPUS:0032579761

SN - 0169-328X

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ER -

Acute 17β-estradiol treatment down-regulates serotonin 5HT(1A) receptor mRNA expression in the limbic system of female rats

Abstract

Keywords

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