TY - JOUR
T1 - Activity of PRC1 and Histone H2AK119 Monoubiquitination
T2 - Revising Popular Misconceptions
AU - Cohen, Idan
AU - Bar, Carmit
AU - Ezhkova, Elena
N1 - Publisher Copyright:
© 2020 WILEY Periodicals, Inc.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Polycomb group proteins are evolutionary conserved chromatin-modifying complexes, essential for the regulation of developmental and cell-identity genes. Polycomb-mediated transcriptional regulation is provided by two multi-protein complexes known as Polycomb repressive complex 1 (PRC1) and 2 (PRC2). Recent studies positioned PRC1 as a foremost executer of Polycomb-mediated transcriptional control. Mammalian PRC1 complexes can form multiple sub-complexes that vary in their core and accessory subunit composition, leading to fascinating and diverse transcriptional regulatory mechanisms employed by PRC1 complexes. These mechanisms include PRC1-catalytic activity toward monoubiquitination of histone H2AK119, a well-established hallmark of PRC1 complexes, whose importance has been long debated. In this review, the central roles that PRC1-catalytic activity plays in transcriptional repression are emphasized and the recent evidence supporting a role for PRC1 complexes in gene activation is discussed.
AB - Polycomb group proteins are evolutionary conserved chromatin-modifying complexes, essential for the regulation of developmental and cell-identity genes. Polycomb-mediated transcriptional regulation is provided by two multi-protein complexes known as Polycomb repressive complex 1 (PRC1) and 2 (PRC2). Recent studies positioned PRC1 as a foremost executer of Polycomb-mediated transcriptional control. Mammalian PRC1 complexes can form multiple sub-complexes that vary in their core and accessory subunit composition, leading to fascinating and diverse transcriptional regulatory mechanisms employed by PRC1 complexes. These mechanisms include PRC1-catalytic activity toward monoubiquitination of histone H2AK119, a well-established hallmark of PRC1 complexes, whose importance has been long debated. In this review, the central roles that PRC1-catalytic activity plays in transcriptional repression are emphasized and the recent evidence supporting a role for PRC1 complexes in gene activation is discussed.
KW - H2AK119ub
KW - Polycomb
KW - catalytic activity
KW - histone modification
KW - polycomb repressive complex 1
KW - polycomb repressive complex 2
KW - transcriptional activation
UR - http://www.scopus.com/inward/record.url?scp=85082694527&partnerID=8YFLogxK
U2 - 10.1002/bies.201900192
DO - 10.1002/bies.201900192
M3 - Review article
C2 - 32196702
AN - SCOPUS:85082694527
SN - 0265-9247
VL - 42
JO - BioEssays
JF - BioEssays
IS - 5
M1 - 1900192
ER -