TY - JOUR
T1 - Activity of PRC1 and Histone H2AK119 Monoubiquitination
T2 - Revising Popular Misconceptions
AU - Cohen, Idan
AU - Bar, Carmit
AU - Ezhkova, Elena
N1 - Funding Information:
I.C. and C.B. contributed equally to this work. I.C. was supported by a Training Program in Stem Cell Biology fellowship from the New York State Department of Health (NYSTEM‐C32561GG). C.B. is a Merksamer Fund scholar. Research in the laboratory of E.E. was supported by the Tisch Cancer Institute P30 Cancer Support Grant, the NIH/NIAMS under award number R01 AR069078, and the NIH/NIDCD under award number R01 DC017400. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Funding Information:
I.C. and C.B. contributed equally to this work. I.C. was supported by a Training Program in Stem Cell Biology fellowship from the New York State Department of Health (NYSTEM-C32561GG). C.B. is a Merksamer Fund scholar. Research in the laboratory of E.E. was supported by the Tisch Cancer Institute P30 Cancer Support Grant, the NIH/NIAMS under award number R01 AR069078, and the NIH/NIDCD under award number R01 DC017400. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2020 WILEY Periodicals, Inc.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Polycomb group proteins are evolutionary conserved chromatin-modifying complexes, essential for the regulation of developmental and cell-identity genes. Polycomb-mediated transcriptional regulation is provided by two multi-protein complexes known as Polycomb repressive complex 1 (PRC1) and 2 (PRC2). Recent studies positioned PRC1 as a foremost executer of Polycomb-mediated transcriptional control. Mammalian PRC1 complexes can form multiple sub-complexes that vary in their core and accessory subunit composition, leading to fascinating and diverse transcriptional regulatory mechanisms employed by PRC1 complexes. These mechanisms include PRC1-catalytic activity toward monoubiquitination of histone H2AK119, a well-established hallmark of PRC1 complexes, whose importance has been long debated. In this review, the central roles that PRC1-catalytic activity plays in transcriptional repression are emphasized and the recent evidence supporting a role for PRC1 complexes in gene activation is discussed.
AB - Polycomb group proteins are evolutionary conserved chromatin-modifying complexes, essential for the regulation of developmental and cell-identity genes. Polycomb-mediated transcriptional regulation is provided by two multi-protein complexes known as Polycomb repressive complex 1 (PRC1) and 2 (PRC2). Recent studies positioned PRC1 as a foremost executer of Polycomb-mediated transcriptional control. Mammalian PRC1 complexes can form multiple sub-complexes that vary in their core and accessory subunit composition, leading to fascinating and diverse transcriptional regulatory mechanisms employed by PRC1 complexes. These mechanisms include PRC1-catalytic activity toward monoubiquitination of histone H2AK119, a well-established hallmark of PRC1 complexes, whose importance has been long debated. In this review, the central roles that PRC1-catalytic activity plays in transcriptional repression are emphasized and the recent evidence supporting a role for PRC1 complexes in gene activation is discussed.
KW - H2AK119ub
KW - Polycomb
KW - catalytic activity
KW - histone modification
KW - polycomb repressive complex 1
KW - polycomb repressive complex 2
KW - transcriptional activation
UR - http://www.scopus.com/inward/record.url?scp=85082694527&partnerID=8YFLogxK
U2 - 10.1002/bies.201900192
DO - 10.1002/bies.201900192
M3 - Review article
C2 - 32196702
AN - SCOPUS:85082694527
SN - 0265-9247
VL - 42
JO - BioEssays
JF - BioEssays
IS - 5
M1 - 1900192
ER -