Active systemic lupus erythematosus is associated with decreased blood conventional dendritic cells

Shaukat Ali Khan, Johannes Nowatzky, Sonia Jiménez-Branda, Jeffrey David Greenberg, Robert Clancy, Jill Buyon, Nina Bhardwaj

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Objective: The aim of the study is to determine the frequency and functionality of blood conventional dendritic cells (cDCs) in relation to disease activity in systemic lupus erythematosus. Methods: Blood cDCs were enumerated for 34 SLE patients, defined as "active" (SLEDAI. ≥. 4) or "inactive" (SLEDAI. <. 4), 26 RA subjects and 8 healthy subjects by FACS. cDC activation was measured by IL-12p40/70 staining following resiquimod stimulation. Results: The frequency of blood cDCs was significantly lower in active compared to inactive patients, however, with comparable cDC functionality. Conclusion: cDC frequency in active SLE is decreased with no perturbation in cDC function, possibly due to enhanced turnover and/or tissue-specific migration.

Original languageEnglish
Pages (from-to)121-123
Number of pages3
JournalExperimental and Molecular Pathology
Volume95
Issue number2
DOIs
StatePublished - Oct 2013
Externally publishedYes

Keywords

  • Autoimmunity
  • Dendritic cells
  • Disease activity
  • Systemic lupus erythematosus

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