TY - JOUR
T1 - Active systemic lupus erythematosus is associated with decreased blood conventional dendritic cells
AU - Khan, Shaukat Ali
AU - Nowatzky, Johannes
AU - Jiménez-Branda, Sonia
AU - Greenberg, Jeffrey David
AU - Clancy, Robert
AU - Buyon, Jill
AU - Bhardwaj, Nina
N1 - Funding Information:
This research was supported by Arthritis Foundation Postdoctoral Fellowship Award #5518 (Nowatzky) , in part by grant 1UL1RR029893 from the Center for Research Resources , NIH (Nowatzky) , Alliance for Lupus Research (Bhardwaj) , NIH R01AI071078 (Bhardwaj) .
PY - 2013/10
Y1 - 2013/10
N2 - Objective: The aim of the study is to determine the frequency and functionality of blood conventional dendritic cells (cDCs) in relation to disease activity in systemic lupus erythematosus. Methods: Blood cDCs were enumerated for 34 SLE patients, defined as "active" (SLEDAI. ≥. 4) or "inactive" (SLEDAI. <. 4), 26 RA subjects and 8 healthy subjects by FACS. cDC activation was measured by IL-12p40/70 staining following resiquimod stimulation. Results: The frequency of blood cDCs was significantly lower in active compared to inactive patients, however, with comparable cDC functionality. Conclusion: cDC frequency in active SLE is decreased with no perturbation in cDC function, possibly due to enhanced turnover and/or tissue-specific migration.
AB - Objective: The aim of the study is to determine the frequency and functionality of blood conventional dendritic cells (cDCs) in relation to disease activity in systemic lupus erythematosus. Methods: Blood cDCs were enumerated for 34 SLE patients, defined as "active" (SLEDAI. ≥. 4) or "inactive" (SLEDAI. <. 4), 26 RA subjects and 8 healthy subjects by FACS. cDC activation was measured by IL-12p40/70 staining following resiquimod stimulation. Results: The frequency of blood cDCs was significantly lower in active compared to inactive patients, however, with comparable cDC functionality. Conclusion: cDC frequency in active SLE is decreased with no perturbation in cDC function, possibly due to enhanced turnover and/or tissue-specific migration.
KW - Autoimmunity
KW - Dendritic cells
KW - Disease activity
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=84880378834&partnerID=8YFLogxK
U2 - 10.1016/j.yexmp.2013.06.003
DO - 10.1016/j.yexmp.2013.06.003
M3 - Article
C2 - 23773850
AN - SCOPUS:84880378834
SN - 0014-4800
VL - 95
SP - 121
EP - 123
JO - Experimental and Molecular Pathology
JF - Experimental and Molecular Pathology
IS - 2
ER -