Activation of the c-myb locus by viral insertional mutagenesis in plasmacytoid lymphosarcomas

Grace L.C. Shen-Ong; Michael Potter; J. Frederic Mushinski; Sukadev Lavu; E. Premkumar Reddy

doi:10.1126/science.6093260

Activation of the c-myb locus by viral insertional mutagenesis in plasmacytoid lymphosarcomas

Grace L.C. Shen-Ong
, Michael Potter
, J. Frederic Mushinski
, Sukadev Lavu
, E. Premkumar Reddy

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

Rearrangement in the c-myb locus of each of four independently derived BALB/c plasmacytoid lymphosarcoma (ABPL's) is due to the insertion of a defective Moloney murine leukemia virus (M-MuLV) into a 1.5-kilobase-pair stretch of cellular DNA at the 5′ end of the v-myb-related sequences. This retroviral insertion is associated with abnormal transcription of myb sequences and probably represents a step in the neoplastic transformation of ABPL cells.

Original language	English
Pages (from-to)	1077-1080
Number of pages	4
Journal	Science
Volume	226
Issue number	4678
DOIs	https://doi.org/10.1126/science.6093260
State	Published - 1984
Externally published	Yes

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title = "Activation of the c-myb locus by viral insertional mutagenesis in plasmacytoid lymphosarcomas",

abstract = "Rearrangement in the c-myb locus of each of four independently derived BALB/c plasmacytoid lymphosarcoma (ABPL's) is due to the insertion of a defective Moloney murine leukemia virus (M-MuLV) into a 1.5-kilobase-pair stretch of cellular DNA at the 5′ end of the v-myb-related sequences. This retroviral insertion is associated with abnormal transcription of myb sequences and probably represents a step in the neoplastic transformation of ABPL cells.",

author = "Shen-Ong, \{Grace L.C.\} and Michael Potter and Mushinski, \{J. Frederic\} and Sukadev Lavu and Reddy, \{E. Premkumar\}",

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doi = "10.1126/science.6093260",

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T1 - Activation of the c-myb locus by viral insertional mutagenesis in plasmacytoid lymphosarcomas

AU - Shen-Ong, Grace L.C.

AU - Potter, Michael

AU - Mushinski, J. Frederic

AU - Lavu, Sukadev

AU - Reddy, E. Premkumar

PY - 1984

Y1 - 1984

N2 - Rearrangement in the c-myb locus of each of four independently derived BALB/c plasmacytoid lymphosarcoma (ABPL's) is due to the insertion of a defective Moloney murine leukemia virus (M-MuLV) into a 1.5-kilobase-pair stretch of cellular DNA at the 5′ end of the v-myb-related sequences. This retroviral insertion is associated with abnormal transcription of myb sequences and probably represents a step in the neoplastic transformation of ABPL cells.

AB - Rearrangement in the c-myb locus of each of four independently derived BALB/c plasmacytoid lymphosarcoma (ABPL's) is due to the insertion of a defective Moloney murine leukemia virus (M-MuLV) into a 1.5-kilobase-pair stretch of cellular DNA at the 5′ end of the v-myb-related sequences. This retroviral insertion is associated with abnormal transcription of myb sequences and probably represents a step in the neoplastic transformation of ABPL cells.

UR - https://www.scopus.com/pages/publications/0021679847

U2 - 10.1126/science.6093260

DO - 10.1126/science.6093260

M3 - Article

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SP - 1077

EP - 1080

JO - Science

JF - Science

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ER -

Activation of the c-myb locus by viral insertional mutagenesis in plasmacytoid lymphosarcomas

Abstract

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