Activation of NF-κB by R5 and X4 human immunodeficiency virus type 1 induces macrophage inflammatory protein 1α and tumor necrosis factor alpha in macrophages

Wonkyu Choe, David J. Volsky, Mary Jane Potash

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

NF-κB is a transcriptional activator that often regulates inflammatory responses. We demonstrate that human immunodeficiency virus type 1 activates nuclear localization of NF-κB in macrophages in a manner dependent upon virus strain but independent of virus replication. Through the use of an inhibitor, NF-κB activation was found to be responsible for the cytokine and chemokine induction that we recently reported.

Original languageEnglish
Pages (from-to)5274-5277
Number of pages4
JournalJournal of Virology
Volume76
Issue number10
DOIs
StatePublished - 2002
Externally publishedYes

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