Activation of an endogenous mouse type C virus by ultraviolet irradiated herpes simplex virus types 1 and 2

B. Hampar; S. A. Aaronson; J. G. Derge; M. Chakrabarty; S. D. Showalter; C. Y. Dunn

doi:10.1073/pnas.73.2.646

Activation of an endogenous mouse type C virus by ultraviolet irradiated herpes simplex virus types 1 and 2

B. Hampar
, S. A. Aaronson
, J. G. Derge
, M. Chakrabarty
, S. D. Showalter
, C. Y. Dunn

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Infection of BALB/c mouse cells with UV irradiated herpes simplex virus (HSV) types 1 and 2, resulted in activation of a xenotropic type C virus detected by infectious center formation in permissive rat cells. The levels of type C virus activated by HSV were related to the UV dose and the multiplicity of infection used. The ability of HSV to activate type C virus was eliminated by heat inactivation and by neutralization with specific antiserum against HSV, but was not affected by purification or treatment with DNase and RNase. Maximum levels of type C virus in the cells and medium were observed within 1 day after HSV infection, and the levels returned to control cell values within 3 to 4 days. The possible significance of these findings with respect to the putative oncogenic potential of HSV is discussed.

Original language	English
Pages (from-to)	646-650
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	73
Issue number	2
DOIs	https://doi.org/10.1073/pnas.73.2.646
State	Published - 1976
Externally published	Yes

Access to Document

10.1073/pnas.73.2.646

Cite this

@article{4654831ba91f4fcaaf19e7cf0140ad9c,

title = "Activation of an endogenous mouse type C virus by ultraviolet irradiated herpes simplex virus types 1 and 2",

abstract = "Infection of BALB/c mouse cells with UV irradiated herpes simplex virus (HSV) types 1 and 2, resulted in activation of a xenotropic type C virus detected by infectious center formation in permissive rat cells. The levels of type C virus activated by HSV were related to the UV dose and the multiplicity of infection used. The ability of HSV to activate type C virus was eliminated by heat inactivation and by neutralization with specific antiserum against HSV, but was not affected by purification or treatment with DNase and RNase. Maximum levels of type C virus in the cells and medium were observed within 1 day after HSV infection, and the levels returned to control cell values within 3 to 4 days. The possible significance of these findings with respect to the putative oncogenic potential of HSV is discussed.",

author = "B. Hampar and Aaronson, \{S. A.\} and Derge, \{J. G.\} and M. Chakrabarty and Showalter, \{S. D.\} and Dunn, \{C. Y.\}",

year = "1976",

doi = "10.1073/pnas.73.2.646",

language = "English",

volume = "73",

pages = "646--650",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "2",

}

TY - JOUR

T1 - Activation of an endogenous mouse type C virus by ultraviolet irradiated herpes simplex virus types 1 and 2

AU - Hampar, B.

AU - Aaronson, S. A.

AU - Derge, J. G.

AU - Chakrabarty, M.

AU - Showalter, S. D.

AU - Dunn, C. Y.

PY - 1976

Y1 - 1976

N2 - Infection of BALB/c mouse cells with UV irradiated herpes simplex virus (HSV) types 1 and 2, resulted in activation of a xenotropic type C virus detected by infectious center formation in permissive rat cells. The levels of type C virus activated by HSV were related to the UV dose and the multiplicity of infection used. The ability of HSV to activate type C virus was eliminated by heat inactivation and by neutralization with specific antiserum against HSV, but was not affected by purification or treatment with DNase and RNase. Maximum levels of type C virus in the cells and medium were observed within 1 day after HSV infection, and the levels returned to control cell values within 3 to 4 days. The possible significance of these findings with respect to the putative oncogenic potential of HSV is discussed.

AB - Infection of BALB/c mouse cells with UV irradiated herpes simplex virus (HSV) types 1 and 2, resulted in activation of a xenotropic type C virus detected by infectious center formation in permissive rat cells. The levels of type C virus activated by HSV were related to the UV dose and the multiplicity of infection used. The ability of HSV to activate type C virus was eliminated by heat inactivation and by neutralization with specific antiserum against HSV, but was not affected by purification or treatment with DNase and RNase. Maximum levels of type C virus in the cells and medium were observed within 1 day after HSV infection, and the levels returned to control cell values within 3 to 4 days. The possible significance of these findings with respect to the putative oncogenic potential of HSV is discussed.

UR - https://www.scopus.com/pages/publications/0017261341

U2 - 10.1073/pnas.73.2.646

DO - 10.1073/pnas.73.2.646

M3 - Article

C2 - 174117

AN - SCOPUS:0017261341

SN - 0027-8424

VL - 73

SP - 646

EP - 650

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 2

ER -

Activation of an endogenous mouse type C virus by ultraviolet irradiated herpes simplex virus types 1 and 2

Abstract

Access to Document

Fingerprint

Cite this