Activation of an endogenous mouse type C virus by ultraviolet irradiated herpes simplex virus types 1 and 2

B. Hampar, S. A. Aaronson, J. G. Derge, M. Chakrabarty, S. D. Showalter, C. Y. Dunn

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Infection of BALB/c mouse cells with UV irradiated herpes simplex virus (HSV) types 1 and 2, resulted in activation of a xenotropic type C virus detected by infectious center formation in permissive rat cells. The levels of type C virus activated by HSV were related to the UV dose and the multiplicity of infection used. The ability of HSV to activate type C virus was eliminated by heat inactivation and by neutralization with specific antiserum against HSV, but was not affected by purification or treatment with DNase and RNase. Maximum levels of type C virus in the cells and medium were observed within 1 day after HSV infection, and the levels returned to control cell values within 3 to 4 days. The possible significance of these findings with respect to the putative oncogenic potential of HSV is discussed.

Original languageEnglish
Pages (from-to)646-650
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume73
Issue number2
DOIs
StatePublished - 1976
Externally publishedYes

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