@article{e571d66cae3d4f608ca05ed1d5e02092,
title = "Activation and regulation of pathogen sensor RIG-I",
abstract = "Cells are equipped with a large set of pattern recognition receptors or sensors that detect foreign molecules such as pathogenic nucleic acids and initiate proinflammatory and antimicrobial innate immune responses. RIG-I is a cytosolic sensor that detects 5'-triphosphate double-stranded RNAs produced during infection. RIG-I is responsible for mounting an antimicrobial response against a variety of viruses and intracellular bacteria. RIG-I contains an intricate structural architecture that allows for efficient signaling downstream in the pathway and autoregulation. The RIG-I-mediated antimicrobial pathway is highly regulated in cells requiring various cofactors, negative regulators, and posttranslational modifications. Modulation of RIG-I and RIG-I-mediated signaling in cells by pathogens to evade recognition and activation of the antimicrobial pathway highlights the essential nature of RIG-I in the innate immune response.",
keywords = "Antiviral response, Innate immunity, RIG-I-like receptors, Type I interferon, Virus",
author = "Patel, {Jenish R.} and Adolfo Garc{\'i}a-Sastre",
note = "Funding Information: Jenish Patel received his BS degree in Biological Sciences from the University of Tennessee, Knoxville, where he was awarded a chancellor's honors research grant for his research in the immunology laboratory of Dr. Thandi Onami and the outstanding graduate award. He was then selected in the APHL-CDC emerging infectious diseases fellowship and performed research on innate immunity to influenza virus in the laboratory of Dr. Suryaprakash Sambhara in the influenza immunology and pathogenesis branch of the influenza division at the Centers for Disease Control and Prevention, Atlanta. He then joined the laboratory of Dr. Adolfo Garc{\'i}a-Sastre for his PhD dissertation research at the Icahn School of Medicine at Mount Sinai, New York, where he currently continues his research as a postdoctoral fellow. His dissertation research has focused on the mechanism of activation of a cytosolic pathogen sensor RIG-I by viral RNA. Publisher Copyright: {\textcopyright} 2014 Elsevier Ltd.",
year = "2014",
month = oct,
day = "1",
doi = "10.1016/j.cytogfr.2014.08.005",
language = "English",
volume = "25",
pages = "513--523",
journal = "Cytokine and Growth Factor Reviews",
issn = "1359-6101",
publisher = "Elsevier BV",
number = "5",
}