Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis

Fionnuala Williams; Ashley Meenagh; Carole Sleator; Daniel Cook; Marcelo Fernandez-Vina; Anne M. Bowcock; Derek Middleton

doi:10.1016/j.humimm.2005.04.005

Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis

Fionnuala Williams, Ashley Meenagh, Carole Sleator, Daniel Cook, Marcelo Fernandez-Vina, Anne M. Bowcock, Derek Middleton

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85 Scopus citations

Abstract

Killer cell immunoglobulin-like receptor genotyping was performed on a cohort of American Caucasian patients with psoriasis to investigate any possible relationship between these chromosome 19 genes and autoimmune-linked disease. This patient cohort also contained a subgroup of patients who had been additionally diagnosed as positive for psoriatic arthritis (PsA). Because of the known association of human leucocyte antigen (HLA)-Cw*06 with psoriasis, the study concentrated on the five KIR genes that have HLA-C as their recognized ligand (i.e., KIR2DL1, -2DL2, -2DL3, -2DS1, and -2DS2). An increase in the frequency of the activating KIR2DS1 gene was detected in the PsA patients, compared with psoriasis patients negative for PsA and an unaffected American Caucasian control group.

Original language	English
Pages (from-to)	836-841
Number of pages	6
Journal	Human Immunology
Volume	66
Issue number	7
DOIs	https://doi.org/10.1016/j.humimm.2005.04.005
State	Published - Jul 2005
Externally published	Yes

Keywords

Autoimmune disease
KIR2DS1
Psoriasis
Psoriatic arthritis

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title = "Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis",

abstract = "Killer cell immunoglobulin-like receptor genotyping was performed on a cohort of American Caucasian patients with psoriasis to investigate any possible relationship between these chromosome 19 genes and autoimmune-linked disease. This patient cohort also contained a subgroup of patients who had been additionally diagnosed as positive for psoriatic arthritis (PsA). Because of the known association of human leucocyte antigen (HLA)-Cw*06 with psoriasis, the study concentrated on the five KIR genes that have HLA-C as their recognized ligand (i.e., KIR2DL1, -2DL2, -2DL3, -2DS1, and -2DS2). An increase in the frequency of the activating KIR2DS1 gene was detected in the PsA patients, compared with psoriasis patients negative for PsA and an unaffected American Caucasian control group.",

keywords = "Autoimmune disease, KIR2DS1, Psoriasis, Psoriatic arthritis",

author = "Fionnuala Williams and Ashley Meenagh and Carole Sleator and Daniel Cook and Marcelo Fernandez-Vina and Bowcock, {Anne M.} and Derek Middleton",

year = "2005",

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T1 - Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis

AU - Williams, Fionnuala

AU - Meenagh, Ashley

AU - Sleator, Carole

AU - Cook, Daniel

AU - Fernandez-Vina, Marcelo

AU - Bowcock, Anne M.

AU - Middleton, Derek

PY - 2005/7

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AB - Killer cell immunoglobulin-like receptor genotyping was performed on a cohort of American Caucasian patients with psoriasis to investigate any possible relationship between these chromosome 19 genes and autoimmune-linked disease. This patient cohort also contained a subgroup of patients who had been additionally diagnosed as positive for psoriatic arthritis (PsA). Because of the known association of human leucocyte antigen (HLA)-Cw*06 with psoriasis, the study concentrated on the five KIR genes that have HLA-C as their recognized ligand (i.e., KIR2DL1, -2DL2, -2DL3, -2DS1, and -2DS2). An increase in the frequency of the activating KIR2DS1 gene was detected in the PsA patients, compared with psoriasis patients negative for PsA and an unaffected American Caucasian control group.

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KW - KIR2DS1

KW - Psoriasis

KW - Psoriatic arthritis

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Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis

Abstract

Keywords

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